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Prepublished online as a Blood First Edition Paper on May 24, 2002; DOI 10.1182/blood-2002-01-0214. This Article Full Text (PDF) All Versions of this Article: 2002-01-0214v1 100/8/2852    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ferrero, I. Articles by MacDonald, H R Search for Related Content PubMed PubMed Citation Articles by Ferrero, I. Articles by MacDonald, H R Social Bookmarking                   What's this? Submitted January 28, 2002 Accepted December 31, 1969 Mouse CD11c+ B220+ Gr1+ plasmacytoid dendritic cells develop independently of the T cell lineage Isabel Ferrero, Werner Held, Anne Wilson, Fabienne Tacchini-Cottier, Freddy Radtke, and H R MacDonald* Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne Branch, University of Lausanne, Epalinges, Switzerland WHO Immunology Research and Training Center, Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland * Corresponding author; email: Hughrobson.Macdonald{at}isrec.unil.ch. The developmental origin of dendritic cells (DC) is controversial. In the mouse CD8+ and CD8- DC subsets are often considered to be of lymphoid and myeloid origin respectively, although evidence on this point is conflicting. Very recently a novel CD11c+ B220+ DC subset has been identified that appears to be the murine counterpart to IFN-producing human plasmacytoid DC (PDC). We show here that CD11c+ B220+ mouse PDC, like human PDC, are present in the thymus and express T lineage markers such as CD8 and CD4. However the intrathymic development of PDC can be completely dissociated from immature T lineage cells in mixed chimeras established with bone marrow cells from mice deficient for either Notch1 or T cell factor 1, two independent mutations that severely block early T cell development. Our data indicate that thymic PDC do not arise from a bipotential T/DC precursor. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Li, J. Park, D. Foss, and I. Goldschneider Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus J. Exp. Med., March 16, 2009; 206(3): 607 - 622. [Abstract] [Full Text] [PDF] U. Koch, A. Wilson, M. Cobas, R. Kemler, H. R. MacDonald, and F. 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