SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on May 17, 2002; DOI 10.1182/blood-2002-01-0256. This Article Full Text (PDF) All Versions of this Article: 2002-01-0256v1 100/4/1493    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gregg, X. T Articles by Prchal, J. T Search for Related Content PubMed PubMed Citation Articles by Gregg, X. T Articles by Prchal, J. T Social Bookmarking                   What's this? Submitted January 31, 2002 Accepted April 1, 2002 Copper Deficiency Masquerading as Myelodysplastic Syndrome Xylina T Gregg, Vishnu T Reddy, and Josef T Prchal* Department of Medicine, Baylor College, Houston, TX, USA Depatment of Pathology, University of Alabama at Birmingham, Birmingham Alabama, AL, USA * Corresponding author; email: JPrchal{at}bcm.tmc.edu. We describe a severely neutropenic, red cell transfusion dependent female, with previous Bilroth II surgery, whose marrow morphology was typical of myelodysplastic syndrome (MDS) with ringed sideroblasts. She had a transient reversal of her anemia and severe neutropenia following erythropoietin and granulocyte colony stimulating factor therapy. Because of relapse while on growth factors, she was referred for allogeneic bone marrow transplantation and a pre-transplant nutritional evaluation revealed severe copper deficiency; her hematological abnormalities fully resolved with copper therapy. This report underscores that copper deficiency should be an integral part of the differential diagnosis of sideroblastic MDS, even in patients not requiring parenteral nutrition. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Videt-Gibou, S. Belliard, E. Bardou-Jacquet, M.-B. Troadec, C. Le Lan, A.-M. Jouanolle, O. Loreal, J. Rivalan, and P. Brissot Iron excess treatable by copper supplementation in acquired aceruloplasminemia: a new form of secondary human iron overload? Blood, September 10, 2009; 114(11): 2360 - 2361. [Full Text] [PDF] L. Sutton, M. Vusirikala, and W. Chen Hematogone Hyperplasia in Copper Deficiency Am J Clin Pathol, August 1, 2009; 132(2): 191 - 199. [Abstract] [Full Text] [PDF] A. Orazi and M. B. Czader Myelodysplastic Syndromes Am J Clin Pathol, August 1, 2009; 132(2): 290 - 305. [Abstract] [Full Text] [PDF] R. T. Naismith, J. B. Shepherd, C. C. Weihl, N. T. Tutlam, and A. H. Cross Acute and Bilateral Blindness Due to Optic Neuropathy Associated With Copper Deficiency Arch Neurol, August 1, 2009; 66(8): 1025 - 1027. [Abstract] [Full Text] [PDF] S. P. Nations, P. J. Boyer, L. A. Love, M. F. Burritt, J. A. Butz, G. I. Wolfe, L. S. Hynan, J. Reisch, and J. R. Trivedi Denture cream: An unusual source of excess zinc, leading to hypocupremia and neurologic disease Neurology, August 26, 2008; 71(9): 639 - 643. [Abstract] [Full Text] [PDF] A.S. Haddad, V. Subbiah, A.E. Lichtin, K.S. Theil, and J.P. Maciejewski Hypocupremia and bone marrow failure Haematologica, January 1, 2008; 93(1): e1 - e5. [Abstract] [Full Text] [PDF] T. Fong, R. Vij, A. Vijayan, J. DiPersio, and M. Blinder Copper deficiency: an important consideration in the differential diagnosis of myelodysplastic syndrome Haematologica, October 1, 2007; 92(10): 1429 - 1430. [Abstract] [Full Text] [PDF] N. Kumar Copper Deficiency Myelopathy (Human Swayback) Mayo Clin. Proc., October 1, 2006; 81(10): 1371 - 1384. [Abstract] [Full Text] [PDF] C I Prodan, S S Bottomley, N R Holland, and S E Lind Relapsing hypocupraemic myelopathy requiring high-dose oral copper replacement. J. Neurol. Neurosurg. Psychiatry, September 1, 2006; 77(9): 1092 - 1093. [Abstract] [Full Text] [PDF] C. M. Everett, M. Matharu, and J. Gawler Neuropathy progressing to myeloneuropathy 20 years after partial gastrectomy Neurology, May 9, 2006; 66(9): 1451 - 1451. [Full Text] [PDF] J. Wu, M. Ricker, and J. Muench Copper Deficiency as Cause of Unexplained Hematologic and Neurologic Deficits in Patient with Prior Gastrointestinal Surgery J Am Board Fam Med, March 1, 2006; 19(2): 191 - 194. [Abstract] [Full Text] [PDF] D. P. Steensma and J. M. Bennett The Myelodysplastic Syndromes: Diagnosis and Treatment Mayo Clin. Proc., January 1, 2006; 81(1): 104 - 130. [Abstract] [Full Text] [PDF] N. Kumar, M. A. Elliott, J. D. Hoyer, C. M. Harper Jr, J. E. Ahlskog, and R. L. Phyliky "Myelodysplasia," Myeloneuropathy, and Copper Deficiency Mayo Clin. Proc., July 1, 2005; 80(7): 943 - 946. [Abstract] [PDF] J Rowin and S L Lewis Copper deficiency myeloneuropathy and pancytopenia secondary to overuse of zinc supplementation J. Neurol. Neurosurg. Psychiatry, May 1, 2005; 76(5): 750 - 751. [Abstract] [Full Text] [PDF] P. G. Reeves and L. C. S. DeMars Repletion of Copper-Deficient Rats with Dietary Copper Restores Duodenal Hephaestin Protein and Iron Absorption Experimental Biology and Medicine, May 1, 2005; 230(5): 320 - 325. [Abstract] [Full Text] [PDF] N Kumar and D S Knopman SMON, clioquinol, and copper Postgrad. Med. J., April 1, 2005; 81(954): 227 - 227. [Full Text] [PDF] N. Kumar, J. B. Gross Jr., and J. E. Ahlskog Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration Neurology, July 13, 2004; 63(1): 33 - 39. [Abstract] [Full Text] [PDF] C. I. Prodan, N. R. Holland, P. J. Wisdom, S. S. Bottomley, N. Kumar, J. B. Gross Jr., and J. E. Ahlskog Myelopathy due to copper deficiency Neurology, May 11, 2004; 62(9): 1655 - 1656. [Full Text] [PDF] J. A. Irving, A. Mattman, G. Lockitch, K. Farrell, and L. D. Wadsworth Element of caution: a case of reversible cytopenias associated with excessive zinc supplementation Can. Med. Assoc. J., July 22, 2003; 169(2): 129 - 131. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020