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Prepublished online as a Blood First Edition Paper on July 5, 2002; DOI 10.1182/blood-2002-01-0312. This Article Full Text (PDF) All Versions of this Article: 2002-01-0312v1 100/10/3646    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cremer, I. Articles by Mueller, C. G F Search for Related Content PubMed PubMed Citation Articles by Cremer, I. Articles by Mueller, C. G F Social Bookmarking                   What's this? Submitted February 5, 2002 Accepted June 18, 2002 Long-lived immature dendritic cells mediated by TRANCE-RANK interaction Isabelle Cremer, Marie-Caroline Dieu-Nosjean, Sylvie Marechal, Colette Dezutter-Dambuyant, Sarah Goddard, David Adams, Nathalie Winter, Christine Menetrier-Caux, Catherine Sautes-Fridman, Wolf H Fridman, and Chris G F Mueller* Institut des Cordeliers, INSERM Unite 255, Paris, France Hopital Edouard Herriot, INSERM Unite 346, Lyon, France Liver Unit Laboratories, Queen Elizabeth Hospital, Birmingham, United Kingdom Unite de Genetique Mycobacterienne, Institut Pasteur, Paris, France Centre Leon Berard, INSERM Unite 453, Lyon, France * Corresponding author; email: chmuller{at}infobiogen.fr. Immature dendritic cells (DC) reside in interstitial tissues (int-DC) or in the epidermis, where they capture antigen and thereafter, mature and migrate to draining lymph nodes (LN) where they present processed antigen to T-cells. We have identified int-DC that express both TRANCE (tumor necrosis factor-related activation-induced cytokine) and RANK (receptor activator of NF-B) and have generated these cells from CD34+ human progenitor cells using M-CSF. These CD34+-derived int-DC which are related to macrophages are long-lived but addition of soluble RANK leads to significant reduction of cell viability and Bcl-2 expression. This suggests that constitutive TRANCE-RANK interaction is responsible for CD34+-derived int-DC longevity. Conversely, CD1a+ DC express only RANK and are short-lived. However, they can be rescued from cell death either by recombinant soluble TRANCE or by CD34+-derived int-DC. CD34+-derived int-DC mature in response to LPS plus CD40 ligand (L) and become capable of CCL21/CCL19-mediated chemotaxis and naive T-cell activation. Upon maturation, they loose TRANCE, making them, like CD1a+ DC, dependent on exogenous TRANCE for survival. 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