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Prepublished online as a Blood First Edition Paper on April 30, 2002; DOI 10.1182/blood-2002-02-0350. This Article Full Text (PDF) All Versions of this Article: 2002-02-0350v1 100/6/1935    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Farag, S. S Articles by Caligiuri, M. A Search for Related Content PubMed PubMed Citation Articles by Farag, S. S Articles by Caligiuri, M. A Social Bookmarking                   What's this? Submitted February 4, 2002 Accepted April 11, 2002 Natural Killer Cell Receptors: New Biology and Insights into the Graft versus Leukemia Effect Sherif S Farag*, Todd A Fehniger, Loredana Ruggeri, Andrea Velardi, and Michael A Caligiuri Department of Internal Medicine, Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA Department of Clinical and Experimental Medicine, Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy * Corresponding author; email: farag-1{at}medctr.osu.edu. Natural killer (NK) cells have held great promise for the immunotherapy of cancer for over three decades. However, to date only modest clinical success has been achieved manipulating the NK cell compartment in patients with malignant disease. Progress in the field of NK cell receptors has revolutionized our concept of how NK cells selectively recognize and lyse tumor and virally infected cells while sparing normal cells. Major families of cell surface receptors that inhibit and activate NK cells to lyse target cells have been characterized, including killer immunoglobulin-like receptors (KIR), C-type lectins, and natural cytotoxicity receptors (NCR). Further, identification of NK receptor ligands and their expression on normal and transformed cells completes the information needed to begin development of rational clinical approaches to manipulating receptor/ligand interactions for clinical benefit. Indeed, clinical data suggest that mismatch of NK receptors and ligands during allogeneic bone marrow transplant may be utilized to prevent leukemia relapse. Here, we review how NK cell receptors control natural cytotoxicity and novel approaches to manipulating NK receptor-ligand interactions for the potential benefit of patients with cancer. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. G. Brunstein, J. E. Wagner, D. J. Weisdorf, S. Cooley, H. Noreen, J. N. Barker, T. DeFor, M. R. Verneris, B. R. Blazar, and J. S. Miller Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity Blood, May 28, 2009; 113(22): 5628 - 5634. [Abstract] [Full Text] [PDF] R. La Rocca, M. Fulciniti, T. Lakshmikanth, M. Mesuraca, T. H. Ali, V. Mazzei, N. Amodio, L. Catalano, B. Rotoli, O. Ouerfelli, et al. Early Hematopoietic Zinc Finger Protein Prevents Tumor Cell Recognition by Natural Killer Cells J. Immunol., April 15, 2009; 182(8): 4529 - 4537. [Abstract] [Full Text] [PDF] N. C. Robson, H. 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Papamichail A potential role for hydrocortisone in the positive regulation of IL-15-activated NK-cell proliferation and survival Blood, July 1, 2005; 106(1): 158 - 166. [Abstract] [Full Text] [PDF] C. Imai, S. Iwamoto, and D. Campana Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells Blood, July 1, 2005; 106(1): 376 - 383. [Abstract] [Full Text] [PDF] K. C. Hsu, C. A. Keever-Taylor, A. Wilton, C. Pinto, G. Heller, K. Arkun, R. J. O'Reilly, M. M. Horowitz, and B. Dupont Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes Blood, June 15, 2005; 105(12): 4878 - 4884. [Abstract] [Full Text] [PDF] J. S. Miller, Y. Soignier, A. Panoskaltsis-Mortari, S. A. McNearney, G. H. Yun, S. K. Fautsch, D. McKenna, C. Le, T. E. Defor, L. J. Burns, et al. 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Toyoshima, S. Ota, et al. Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells Blood, August 1, 2004; 104(3): 768 - 774. [Abstract] [Full Text] [PDF] P. Lang, K. Barbin, T. Feuchtinger, J. Greil, M. Peipp, S. J. Zunino, M. Pfeiffer, R. Handgretinger, D. Niethammer, and G. H. Fey Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effector cells from pediatric patients who received T-cell-depleted allografts Blood, May 15, 2004; 103(10): 3982 - 3985. [Abstract] [Full Text] [PDF] C. Demanet, A. Mulder, V. Deneys, M. J. Worsham, P. Maes, F. H. Claas, and S. Ferrone Down-regulation of HLA-A and HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: an escape mechanism from CTL and NK attack? Blood, April 15, 2004; 103(8): 3122 - 3130. [Abstract] [Full Text] [PDF] M. Bornhauser, R. Schwerdtfeger, H. Martin, K.-H. Frank, C. Theuser, G. Ehninger, F. Locatelli, A. Velardi, and S. Giebel Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors Blood, April 1, 2004; 103(7): 2860 - 2861. [Full Text] [PDF] W. Leung, R. Iyengar, V. Turner, P. Lang, P. Bader, P. Conn, D. Niethammer, and R. Handgretinger Determinants of Antileukemia Effects of Allogeneic NK Cells J. Immunol., January 1, 2004; 172(1): 644 - 650. [Abstract] [Full Text] [PDF] M. A. Caligiuri, A. Velardi, D. A. Scheinberg, and I. M. Borrello Immunotherapeutic Approaches for Hematologic Malignancies Hematology, January 1, 2004; 2004(1): 337 - 353. [Abstract] [Full Text] [PDF] R. K. Strair, D. Schaar, D. Medina, M. B. Todd, J. Aisner, R. S. DiPaola, J. Manago, B. Knox, A. Jenkinson, R. Senzon, et al. Antineoplastic Effects of Partially HLA-Matched Irradiated Blood Mononuclear Cells in Patients With Renal Cell Carcinoma J. Clin. Oncol., October 15, 2003; 21(20): 3785 - 3791. [Abstract] [Full Text] [PDF] H. R. Salih, H. Antropius, F. Gieseke, S. Z. Lutz, L. Kanz, H.-G. Rammensee, and A. Steinle Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia Blood, August 15, 2003; 102(4): 1389 - 1396. [Abstract] [Full Text] [PDF] S. Giebel, F. Locatelli, T. Lamparelli, A. Velardi, S. Davies, G. Frumento, R. Maccario, F. Bonetti, J. Wojnar, M. Martinetti, et al. Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors Blood, August 1, 2003; 102(3): 814 - 819. [Abstract] [Full Text] [PDF] J. Xu, R. Lucas, M. Schuchmann, S. Kuhnle, T. Meergans, A. P. Barreiros, A. W. Lohse, G. Otto, and A. Wendel GM-CSF Restores Innate, But Not Adaptive, Immune Responses in Glucocorticoid-Immunosuppressed Human Blood In Vitro J. Immunol., July 15, 2003; 171(2): 938 - 947. [Abstract] [Full Text] [PDF]

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