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Prepublished online as a Blood First Edition Paper on April 30, 2002; DOI 10.1182/blood-2002-02-0400. This Article Full Text (PDF) Erratum (v112,p5259) All Versions of this Article: 2002-02-0400v1 100/6/2243    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Martino, R. Articles by Sierra, J. Search for Related Content PubMed PubMed Citation Articles by Martino, R. Articles by Sierra, J. Social Bookmarking                   What's this? Submitted February 6, 2002 Accepted April 18, 2002 Evidence for a Graft-versus-leukemia Effect after Allogeneic Peripheral Blood Stem Cell Transplantation with Reduced-intensity Conditioning in Acute Myelogenous Leukemia and Myelodysplastic Syndromes Rodrigo Martino*, Maria D Caballero, Jose A Perez-Simon, Carmen Canals, Carlos Solano, Joan Bargay, Angel Leon, Josep Sarra, Alvaro Urbano-Ispizua, Guillermo F Sanz, Jose M Moraleda, Salut Brunet, Jesus F San Miguel, and Jordi Sierra Servei d'Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Hematologia, Hospital Clinico de Salamanca, Salamanca, Spain Hematologia, Hospital Clinico, Universidad de Valencia, Valencia, Spain Hematologia, Hospital Son Dureta, Palma de Mallorca, Spain Hematologia, Hospital SAS, Jerez de la Frontera, Spain Hematologia Clinica, Institut Catala d'Oncologia, l'Hospitalet de Llobregat, Spain Hematologia Clinica, Hospital Clinico de Barcelona, Barcelona, Spain Hematologia Clinica, Hospital La Fe, Valencia, Spain Hematologia, Hospital Morales Meseguer, Murcia, Spain * Corresponding author; email: rmartino{at}hsp.santpau.es. We report the results of a prospective study of a reduced-intensity conditioning (RIC) regimen followed by allogeneic peripheral blood stem cell transplantation (PBSCT) from an HLA-identical sibling in 37 patients with acute myeloid leukemia (AML, n=17) or myelodysplastic syndrome (MDS, n=20). The median age was 57 years, and 22 (59%) were beyond the early phase of their disease. The incidence of grade II-IV acute graft-versus-host disease (GVHD) was 19% (5% grade III-IV), and the 1-year incidence of chronic extensive GVHD was 46%. With a median follow-up of 297 days (355 days in 24 survivors), the 1-year probability of transplant-related mortality was 5%, and the one-year progression-free survival was 66%. The 1-year incidence of disease progression in patients with and without GVHD was 13% (95% CI, 4% to 34%) and 58% (95% CI, 36% to 96%), respectively (P=0.008). 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	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020