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Prepublished online as a Blood First Edition Paper on July 12, 2002; DOI 10.1182/blood-2002-02-0523. This Article Full Text (PDF) All Versions of this Article: 2002-02-0523v1 100/10/3822    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Washington, A. V. Articles by McVicar, D. W Search for Related Content PubMed PubMed Citation Articles by Washington, A. V. Articles by McVicar, D. W Social Bookmarking                   What's this? Submitted February 15, 2002 Accepted June 18, 2002 Initial Characterization of TREM Like Transcript (TLT) -1: A Putative Inhibitory Receptor Within the TREM Cluster A. Valance Washington, Laura Quigley, and Daniel W McVicar* Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Frederick, MD, USA * Corresponding author; email: mcvicar{at}nih.gov. The TREMs (Triggering receptors expressed on myeloid cells) represent a family of 5 receptors clustered on murine chromosome 17. TREMs 1 and 2 affect various aspects of myeloid cell activation and development, including responsiveness to LPS, and regulation of dendritic cell maturation, yet no inhibitory receptor has been demonstrated within this cluster. Here we characterize TLT-1 (TREM like transcript-1), a putative inhibitory receptor within the TREM cluster that contains an extracellular V-set Ig domain, a proline rich region and immune receptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail. To our knowledge TLT-1 is the first ITIM containing receptor carrying a potential Src Homology 3 domain ligand. TLT-1 transcripts are abundant in bone marrow cells, but not lymphocytes, and phosphorylated TLT-1 associates with SHP-1 suggesting that it is indeed an inhibitory receptor. Based on these characteristics it is likely that TLT-1 regulates the signaling of the TREM family receptors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. J.A. Korporaal, C. A. Koekman, S. Verhoef, D. E. van der Wal, M. Bezemer, M. Van Eck, and J.-W. N. Akkerman Downregulation of Platelet Responsiveness Upon Contact With LDL by the Protein-Tyrosine Phosphatases SHP-1 and SHP-2 Arterioscler Thromb Vasc Biol, March 1, 2009; 29(3): 372 - 379. [Abstract] [Full Text] [PDF] P. van Baarlen, F. J. Troost, S. van Hemert, C. van der Meer, W. M. de Vos, P. J. de Groot, G. J. E. J. Hooiveld, R.-J. M. Brummer, and M. 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