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Prepublished online as a Blood First Edition Paper on May 24, 2002; DOI 10.1182/blood-2002-02-0598. This Article Full Text (PDF) All Versions of this Article: 2002-02-0598v1 100/6/2249    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chiang, C.-E. Articles by Ding, P. Y.-A. Search for Related Content PubMed PubMed Citation Articles by Chiang, C.-E. Articles by Ding, P. Y.-A. Social Bookmarking                   What's this? Submitted February 25, 2002 Accepted April 22, 2002 Prolongation of cardiac repolarization by arsenic trioxide Chern-En Chiang*, Hsiang-Ning Luk, Tsui-Min Wang, and Philip Yu-An Ding Division of Cardiology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan Department of Anesthesiology, Chang-Gung Memorial Hospital, Taipei, Taiwan Graduate Institute of Medical Science, Taipei Medical University, Taipei, Taiwan * Corresponding author; email: cechiang{at}vghtpe.gov.tw. Arsenic trioxide (ATO) has recently been found to be very effective for relapsed acute promyelocytic leukemia. Several articles reported prolongation of QT interval or ventricular arrhythmias in patients receiving ATO. However, the QT-prolonging effect has not been confirmed and the direct membrane effect of ATO has never been studied. In the present study, using conventional action potential recording technique, we found that ATO dose-dependently prolonged action potential duration in guinea pig papillary muscle with a slow pacing frequency. Parenteral administration of ATO prolonged QT interval and action potential duration in guinea pig hearts. Intravenous infusion of clinically relevant doses of ATO prolonged QT interval and action potential duration dose-dependently. These studies suggest that ATO has a direct effect on cardiac repolarization. Patients who are receiving ATO had better avoid concomitant administration of other QT-prolonging agents, or conditions in favor of delaying cardiac repolarization. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. N. Katchman, J. Koerner, T. Tosaka, R. L. Woosley, and S. N. Ebert Comparative Evaluation of HERG Currents and QT Intervals following Challenge with Suspected Torsadogenic and Nontorsadogenic Drugs J. Pharmacol. Exp. Ther., March 1, 2006; 316(3): 1098 - 1106. [Abstract] [Full Text] [PDF] M. W Lai, E. W Boyer, M. E Kleinman, N. M Rodig, and M. B. Ewald Acute Arsenic Poisoning in Two Siblings Pediatrics, July 1, 2005; 116(1): 249 - 257. [Abstract] [Full Text] [PDF] E. Ficker, Y. A. Kuryshev, A. T. Dennis, C. Obejero-Paz, L. Wang, P. Hawryluk, B. A. Wible, and A. M. Brown Mechanisms of Arsenic-Induced Prolongation of Cardiac Repolarization Mol. Pharmacol., July 1, 2004; 66(1): 33 - 44. [Abstract] [Full Text] [PDF] B. Drolet, C. Simard, and D. M. Roden Unusual Effects of a QT-Prolonging Drug, Arsenic Trioxide, on Cardiac Potassium Currents Circulation, January 6, 2004; 109(1): 26 - 29. [Abstract] [Full Text] [PDF]

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