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Prepublished online as a Blood First Edition Paper on August 1, 2002; DOI 10.1182/blood-2002-02-0602.
Submitted February 25, 2002
Accepted July 15, 2002
Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fc receptor I cross-linking: an interspecies comparison
Toshiharu Nakajima, Naoki Inagaki, Hiroyuki Tanaka, Akane Tanaka, Mamoru Yoshikawa, Mayumi Tamari, Koichi Hasegawa, Kenji Matsumoto, Hiroshi Tachimoto, Motohiro Ebisawa, Gozoh Tsujimoto, Hiroshi Matsuda, Hiroichi Nagai, and Hirohisa Saito*
Department of Allergy and Immunology, National Research Institute for Child Health & Development, Tokyo, Japan
Department of Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
Department of Veterinary Clinic, Tokyo University of Agriculture and Technology, Tokyo, Japan
Laboratory for Functional Analysis, RIKEN SNP Research Center, Yokohama, Japan
Department of Allergy and Immunology, National Research Institute for Child Health & Development, Tokyo, Japan; Research Team for Allergy Transcriptome, RIKEN Research Center for Allergy & Immunology, Yokohama, Japan
Department of Pediatrics, National Sagamihara Hospital, Sagamihara, Japan
Department of Molecular Pharmacology, National Research Institute for Child Health & Development, Tokyo, Japan
* Corresponding author; email: hsaito{at}nch.go.jp.
Rodent mast cells (MCs) are common experimental tools but are somewhat different from their human counterparts in terms of sensitivity to some cytokines and drugs. We thus examined >10,000 kinds of gene expression in human and cultured mouse MCs using high-density oligonucleotide probe arrays (GeneChip) to find molecules similarly regulated and expressed by the two MC types. After stimulation via high-affinity Fc receptor (FcRI), the transcriptional levels of several CC chemokines were markedly increased, and I-309 (CCL1), macrophage inflammatory protein-1 (MIP-1) (CCL3) and MIP-1ß (CCL4) were found in the 10 most-increased human and mouse transcripts among approximately 12,000 genes (including some expressed sequence tags). In addition, a costimulatory molecule that is originally found on the membrane of activated T cells, 4-1BB (CD137) was found in the 10 most-increased transcripts. The FcRI-mediated expression of CC chemokines and 4-1BB was also detected at the protein levels in both MC types. These results suggest that MCs play a crucial role in recruitment of various CCR-expressing cells into the tissue in an IgE-dependent manner, and that FcRI-mediated induction of several CC chemokines and 4-1BB as an activation marker of MCs is highly conserved between human and mouse. Interspecies comparison studies at the whole genome expression level should be useful for the interpretation of experimental data obtained in animal models of human pathobiology.
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