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Prepublished online as a Blood First Edition Paper on July 5, 2002; DOI 10.1182/blood-2002-02-0638. This Article Full Text (PDF) All Versions of this Article: 2002-02-0638v1 100/9/3295    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rissoan, M.-C. Articles by Bates, E. E Search for Related Content PubMed PubMed Citation Articles by Rissoan, M.-C. Articles by Bates, E. E Social Bookmarking                   What's this? Submitted March 1, 2002 Accepted June 13, 2002 Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and three novel transcripts in human plasmacytoid dendritic cells Marie-Clotilde Rissoan, Thomas Duhen, Jean-Michel Bridon, Nathalie Bendriss-Vermare, Catherine Peronne, Blandine de Saint Vis, Francine Briere*, and Elizabeth E Bates Laboratory for Immunological Research, Schering-Plough, Dardilly, France * Corresponding author; email: francine.briere{at}spcorp.com. Recent studies in human have highlighted the importance of a distinct cellular entity, the plasmacytoid dendritic cell (PDC). To identify genes, the expression of which is restricted to human PDC, a cDNA subtraction technique was applied using cDNA from activated monocyte-derived DC (MDDC) as competitor. In the 650 sequences analyzed, 25% were for B cell transcripts. We also found lymphoid-related genes; immunoglobulin-like transcript 7 (ILT7), granzyme B (GrB), Spi-B, and the receptor tyrosine kinase Eph-B1. Granzyme B was upregulated upon activation, and protein was detected only in PDC. Eph-B1 protein was expressed in the cytoplasm and the nucleus of PDC and MDDC respectively. Interestingly, several novel molecules have been identified that were predicted to encode for a type 2 transmembrane protein (BRI 3), a putative cytokine (C-15, a cysteine-rich secreted protein), and a type I leucine-rich repeat protein (MAPA). The identification of genes expressed in PDC provides new insights on their function and origin. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. A. Ngan, S. V. Vickerman, D. J. Granville, S. F. P. Man, and D. D. 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