|
|
Prepublished online as a Blood First Edition Paper on June 7, 2002; DOI 10.1182/blood-2002-02-0654.
Submitted February 28, 2002
Accepted May 27, 2002
Human leukocyte antigens class II (HLA DRB1) and tumor necrosis factor genetic polymorphisms are independent predictors of non-Hodgkin's lymphoma outcome
Przemyslaw Juszczynski, Ewa Kalinka, Jacques Bienvenu, Grzegorz Woszczek, Maciej Borowiec, Tadeusz Robak, Marek Kowalski, Ewa Lech-Maranda, Lucile Baseggio, Bertrand Coiffier, Gilles Salles, and Krzysztof Warzocha*
Hematology, Medical University of Lodz, Lodz, Poland
Jeune Equipe, Universite Claude Bernard, Lyon, France
Clinical Immunology, Medical University of Lodz, Lodz, Poland
Hematology, Medical University of Lodz, Lodz, Poland; Jeune Equipe, Universite Claude Bernard, Lyon, France
Service d'Hematologie, Centre Hospitalier Lyon-Sud, Lyon, France; Jeune Equipe, Universite Claude Bernard, Lyon, France
* Corresponding author; email: warzocha{at}psk2.am.lodz.pl.
Tumor necrosis factor (TNF) production and non-Hodgkin's lymphoma (NHL) outcome was found to be related to the TNF-308 polymorphism. To explore whether this could be linked to neighboring polymorphisms, we genotyped the TNF-376,-308,-238,-163, lymphotoxin alpha (LT )+252, and HLA DRB1 alleles in 204 NHL patients and 120 controls. TNF-308A was the only allele associated with higher TNF and its p55 and p75 receptors' levels (p=.009, p=.03, and p=.007) and lower complete remission rates (p=.006). Freedom from progression (FFP) and overall survival (OS) were shorter in patients with TNF-308A (p=.009 and p=.02), null HLA DRB1*02 allele (p=.007 and p=.14), or both genetic markers (p=.004 and p=.005). Multivariate analysis incorporating International Prognostic Index (IPI) identified TNF-308A (p<.0001, relative risk [RR]=1.63; p<.0001, RR=1.51) and null HLA DRB1*02 alleles (p=.015, RR=1.18; p<.0001, RR=1.25) as independent factors for FFP and OS. These results indicate the existence of at least two inherited factors involved in NHL outcome.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. J. Novak, S. L. Slager, Z. S. Fredericksen, A. H. Wang, M. M. Manske, S. Ziesmer, M. Liebow, W. R. Macon, S. R. Dillon, T. E. Witzig, et al.
Genetic Variation in B-Cell-Activating Factor Is Associated with an Increased Risk of Developing B-Cell Non-Hodgkin Lymphoma
Cancer Res.,
May 15, 2009;
69(10):
4217 - 4224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Anderson, R. M. Pfeiffer, J. S. Rapkin, G. Gridley, L. Mellemkjaer, K. Hemminki, M. Bjorkholm, N. E. Caporaso, and O. Landgren
Survival Patterns Among Lymphoma Patients With a Family History of Lymphoma
J. Clin. Oncol.,
October 20, 2008;
26(30):
4958 - 4965.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Habermann, S. S. Wang, M. J. Maurer, L. M. Morton, C. F. Lynch, S. M. Ansell, P. Hartge, R. K. Severson, N. Rothman, S. Davis, et al.
Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era
Blood,
October 1, 2008;
112(7):
2694 - 2702.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Cerhan, S. M. Ansell, Z. S. Fredericksen, N. E. Kay, M. Liebow, T. G. Call, A. Dogan, J. M. Cunningham, A. H. Wang, W. Liu-Mares, et al.
Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma
Blood,
December 15, 2007;
110(13):
4455 - 4463.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Diepstra, G. W. van Imhoff, H. E. Karim-Kos, A. van den Berg, G. J. te Meerman, M. Niens, I. M. Nolte, E. Bastiaannet, M. Schaapveld, E. Vellenga, et al.
HLA Class II Expression by Hodgkin Reed-Sternberg Cells Is an Independent Prognostic Factor in Classical Hodgkin's Lymphoma
J. Clin. Oncol.,
July 20, 2007;
25(21):
3101 - 3108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Cerhan, S. Wang, M. J. Maurer, S. M. Ansell, S. M. Geyer, W. Cozen, L. M. Morton, S. Davis, R. K. Severson, N. Rothman, et al.
Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival
Blood,
June 15, 2007;
109(12):
5439 - 5446.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Lech-Maranda, P. Juszczynski, A. Szmigielska-Kaplon, K. Jamroziak, E. Balcerczak, and T. Robak
Human leukocyte antigens HLA DRB1 influence clinical outcome of chronic lymphocytic leukemia
Haematologica,
May 1, 2007;
92(5):
710 - 711.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Wang, J. R. Cerhan, P. Hartge, S. Davis, W. Cozen, R. K. Severson, N. Chatterjee, M. Yeager, S. J. Chanock, and N. Rothman
Common Genetic Variants in Proinflammatory and Other Immunoregulatory Genes and Risk for Non-Hodgkin Lymphoma
Cancer Res.,
October 1, 2006;
66(19):
9771 - 9780.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.J. BISSELL, P.A. KENNY, and D.C. RADISKY
Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes
Cold Spring Harb Symp Quant Biol,
January 1, 2005;
70(0):
343 - 356.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Lech-Maranda, L. Baseggio, J. Bienvenu, C. Charlot, F. Berger, D. Rigal, K. Warzocha, B. Coiffier, and G. Salles
Interleukin-10 gene promoter polymorphisms influence the clinical outcome of diffuse large B-cell lymphoma
Blood,
May 1, 2004;
103(9):
3529 - 3534.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. J. Kim, H.-S. Lee, J.-H. Yoon, C. Y. Kim, M. H. Park, L. H. Kim, B. L. Park, and H. D. Shin
Association of TNF-{alpha} promoter polymorphisms with the clearance of hepatitis B virus infection
Hum. Mol. Genet.,
October 1, 2003;
12(19):
2541 - 2546.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
