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Prepublished online as a Blood First Edition Paper on October 10, 2002; DOI 10.1182/blood-2002-03-0764. This Article Full Text (PDF) All Versions of this Article: 2002-03-0764v1 101/4/1611    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Locatelli, F. W Articles by Frassoni, F. Search for Related Content PubMed PubMed Citation Articles by Locatelli, F. W Articles by Frassoni, F. Social Bookmarking                   What's this? Submitted March 18, 2002 Accepted August 7, 2002 Factors influencing outcome and incidence of long-term complications in children given autologous stem cell transplantation for acute myeloid leukemia in 1st complete remission Franco W Locatelli*, Myriam Labopin, Juan Ortega, Giovanna Meloni, Giorgio Dini, Chiara Messina, Isaac Yaniv, Franca Fagioli, Victoria Castel, Peter J Shaw, Augustin Ferrant, Andrea Pession, Gerard Socie, and Francesco Frassoni Universita' di Pavia, Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy EBMT, European Data Management Office, Paris, France Vall d'Hebron, Hospital Materno Infantil, Barcelona, Spain Universita' La Sapienza, Dipartimento di Biotecnologie Cellulari ed Ematologia, Rome, Italy Istituto G. Gaslini, Dipartimento di Ematologia ed Oncologia, Genova, Italy Universita' di Padova, Clinica Pediatrica, Padova, Italy Schneider Children's Medical Center of Israel, BMT Unit, Petach-Tikva, Israel Universita' di Torino, Clinica Pediatrica, Turin, Italy Hospital Infantil La Fe, Valencia, Spain Children Hospital at Westmead, Oncology Unit, Sydney, Australia Cliniques Universitaires St Luc, Brussels, Belgium Universita' di Bologna, Clinica Pediatrica, Bologna, Italy Hopital Saint-Louis, Department of Hematology, BMT Unit, Paris, France Ospedale San Martino, Divisione di Ematologia II, Genova, Italy * Corresponding author; email: f.locatelli{at}smatteo.pv.it. In order to evaluate factors influencing outcome and incidence of long-term complications, we analyzed, in a retrospective, multi-center study, 387 children given an autologous hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia (AML) in 1st complete remission (CR). Median follow-up time from transplantation was 60 months. Transplant of bone marrow cells was performed in 318 children, whereas in 60 patients peripheral blood progenitor cells (PBPC) were employed. In multivariate analysis, we investigated the variables influencing probability of hematopoietic recovery, transplant-related mortality (TRM), relapse, and leukemia-free survival (LFS). We found that use of PBPC as stem-cell source and use of BAVC as preparative regimen were associated with faster neutrophil recovery. Infusion of PBPC, young age, use of BAVC and no marrow purging predicted an accelerated platelet reconstitution. The 5-year Kaplan-Meier estimates of TRM, relapse and LFS were 3±1%, 39±3% and 60±3%, respectively. Relapse probability was increased in children given BAVC regimen and decreased after in vitro purging of hematopoietic progenitors, as well as in children with FAB M3 and a time interval between CR and HSCT 170 days. These 2 latter variables favourably influenced the probability of LFS, which was, by contrast, reduced with BAVC regimen. Thirty-three percent of patients surviving more than 18 months developed at least one late sequel, use of total body irradiation being the only predictive factor. The results obtained in this analysis can be of help in designing prospective studies autologous HSCT in children with AML in 1st CR. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Morra, G. Barosi, A. Bosi, F. Ferrara, F. Locatelli, M. Marchetti, G. Martinelli, C. Mecucci, M. Vignetti, and S. Tura Clinical management of primary non-acute promyelocytic leukemia acute myeloid leukemia: practice Guidelines by the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation Haematologica, January 1, 2009; 94(1): 102 - 112. [Abstract] [Full Text] [PDF] N. J. Bunin, S. M. Davies, R. Aplenc, B. M. Camitta, K. B. DeSantes, R. K. Goyal, N. Kapoor, N. A. Kernan, J. Rosenthal, F. O. Smith, et al. Unrelated Donor Bone Marrow Transplantation for Children With Acute Myeloid Leukemia Beyond First Remission or Refractory to Chemotherapy J. Clin. Oncol., September 10, 2008; 26(26): 4326 - 4332. [Abstract] [Full Text] [PDF] F. Locatelli, P. Nollke, M. Zecca, E. Korthof, E. Lanino, C. Peters, A. Pession, H. Kabisch, C. Uderzo, C. S. Bonfim, et al. Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial Blood, January 1, 2005; 105(1): 410 - 419. [Abstract] [Full Text] [PDF]

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