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Prepublished online as a Blood First Edition Paper on July 18, 2002; DOI 10.1182/blood-2002-03-0809. This Article Full Text (PDF) All Versions of this Article: 2002-03-0809v1 100/12/4074    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by de Andres, B. Articles by Gaspar, M. L. Search for Related Content PubMed PubMed Citation Articles by de Andres, B. Articles by Gaspar, M. L. Social Bookmarking                   What's this? Submitted March 20, 2002 Accepted July 8, 2002 The first three days of B cell development in the mouse embryo Belen de Andres, Pilar Gonzalo, Susana Minguet, Jose A Martinez-M, Pilar G Soro, Miguel Angel R Marcos, and Maria Luisa Gaspar* Unidad de Inmunobiologia, Instituto de Salud Carlos III (ISCIII), Majadahonda 28220, Madrid, Spain Centro de Biologia Molecular Severo Ochoa (CBMSO), Cantoblanco 28049, Madrid, Spain * Corresponding author; email: mlgaspar{at}isciii.es. B lineage-committed cells are believed to arise in the liver of mouse embryos at 14 days post-coitum (dpc). However, pre-B-specific gene transcripts and DJH gene rearrangements have been detected in earlier, midgestation embryos. We describe here a population of c-kit+AA4.1+CD19+Pax5+ cells present in the aorta-gonad-mesonephros (AGM) area and in liver of 11-dpc mouse embryos. In contrast to multipotent c-kit+AA4.1+CD19- hematopoietic stem cells (HSC), these c-kit+AA4.1+CD19+ progenitors differentiated only to B lineage cells in vitro. We propose that mouse embryonic B lymphopoiesis starts earlier than previously thought, at 10-11 dpc, both in liver and extra-liver hematopoietic sites. The B-cell differentiation program is not delayed with respect to the emerging lymphohematopoiesis events in the midgestation mouse embryo (8-9 dpc). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. L. Esplin, R. S. Welner, Q. Zhang, L. A. Borghesi, and P. W. Kincade A differentiation pathway for B1 cells in adult bone marrow PNAS, April 7, 2009; 106(14): 5773 - 5778. [Abstract] [Full Text] [PDF] B. Gozalbo-Lopez, P. Andrade, G. Terrados, B. de Andres, N. Serrano, I. Cortegano, B. Palacios, A. Bernad, L. Blanco, M. A. R. Marcos, et al. A Role for DNA Polymerase {micro} in the Emerging DJH Rearrangements of the Postgastrulation Mouse Embryo Mol. Cell. Biol., March 1, 2009; 29(5): 1266 - 1275. [Abstract] [Full Text] [PDF] B. de Andres, I. Cortegano, N. Serrano, B. del Rio, P. Martin, P. Gonzalo, M. A. R. Marcos, and M. L. Gaspar A Population of CD19highCD45R /lowCD21low B Lymphocytes Poised for Spontaneous Secretion of IgG and IgA Antibodies J. Immunol., October 15, 2007; 179(8): 5326 - 5334. [Abstract] [Full Text] [PDF] T. Yokota, J. Huang, M. Tavian, Y. Nagai, J. Hirose, J.-C. Zuniga-Pflucker, B. Peault, and P. W. Kincade Tracing the first waves of lymphopoiesis in mice Development, May 15, 2006; 133(10): 2041 - 2051. [Abstract] [Full Text] [PDF] R. Haddad, P. Guardiola, B. Izac, C. Thibault, J. Radich, A.-L. Delezoide, C. Baillou, F. M. Lemoine, J. C. Gluckman, F. Pflumio, et al. Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord blood Blood, December 15, 2004; 104(13): 3918 - 3926. [Abstract] [Full Text] [PDF]

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