SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on June 7, 2002; DOI 10.1182/blood-2002-03-0822. This Article Full Text (PDF) All Versions of this Article: 2002-03-0822v1 100/7/2665    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Abkowitz, J. L Articles by Guttorp, P. Search for Related Content PubMed PubMed Citation Articles by Abkowitz, J. L Articles by Guttorp, P. Related Collections Related Letter in Blood Online Social Bookmarking                   What's this? Submitted March 15, 2002 Accepted May 19, 2002 Evidence that the number of hematopoietic stem cells per animal is conserved in mammals Janis L Abkowitz*, Sandra N Catlin, Monica T McCallie, and Peter Guttorp Department of Medicine, University of Washington, Seattle, WA, USA Department of Mathematical Statistics, University of Nevada, Las Vegas, Las Vegas, NV, USA Department of Statistics, University of Washington, Seattle, WA, USA * Corresponding author; email: janabk{at}u.washington.edu. Man and larger mammals require more blood cells per lifetime than mouse, because of their larger size and longer life expectancy. To investigate this evolutionary adaptation, we calculated the total number of nucleated marrow cells (NMC) per cat observing the distribution of 59Fe to marrow, then multiplied this value (1.9 ± 0.9 x 1010 (mean ± SD)) times the frequency of feline HSC (6 HSC/107 NMC) to derive the total number of HSC per cat (11,400 ± 5,400). Surprisingly, when the total number of HSC per mouse was calculated with a similar experimental and computational approach, the value was equivalent. These data imply that the output of differentiated cells per feline HSC must vastly exceed that of murine HSC. Furthermore, if the total number of human HSC were also equivalent to cat and mouse, the frequency of human HSC would be 0.7 - 1.5 HSC/108 NMC, a frequency that is 20-fold less than estimated by the NOD/SCID repopulating assay. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Of mice and men ... and elephants Myrtle Y. Gordon, John L. Lewis, and Stephen B. Marley Blood 2002 100: 4679. [Full Text] [PDF] This article has been cited by other articles: J. L. Herrmann, A. M. Abarbanell, B. R. Weil, Y. Wang, M. Wang, J. Tan, and D. R. Meldrum Cell-based therapy for ischemic heart disease: a clinical update. Ann. Thorac. Surg., November 1, 2009; 88(5): 1714 - 1722. [Abstract] [Full Text] [PDF] H. Haeno, R. L. Levine, D. G. Gilliland, and F. Michor A progenitor cell origin of myeloid malignancies PNAS, September 29, 2009; 106(39): 16616 - 16621. [Abstract] [Full Text] [PDF] B. J. Lannutti, A. Epp, J. Roy, J. Chen, and N. C. Josephson Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis Blood, February 19, 2009; 113(8): 1778 - 1785. [Abstract] [Full Text] [PDF] D. Dingli, L. Luzzatto, and J. M. Pacheco Neutral evolution in paroxysmal nocturnal hemoglobinuria PNAS, November 25, 2008; 105(47): 18496 - 18500. [Abstract] [Full Text] [PDF] D. Dingli, A. Traulsen, and J. M Pacheco Dynamics of haemopoiesis across mammals Proc R Soc B, October 22, 2008; 275(1649): 2389 - 2392. [Abstract] [Full Text] [PDF] A. Liso, F. Castiglione, A. Cappuccio, F. Stracci, R. F. Schlenk, S. Amadori, C. Thiede, S. Schnittger, P. J.M. Valk, K. Dohner, et al. A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1) Haematologica, August 1, 2008; 93(8): 1219 - 1226. [Abstract] [Full Text] [PDF] L. A. Thoren, K. Liuba, D. Bryder, J. M. Nygren, C. T. Jensen, H. Qian, J. Antonchuk, and S.-E. W. Jacobsen Kit Regulates Maintenance of Quiescent Hematopoietic Stem Cells J. Immunol., February 15, 2008; 180(4): 2045 - 2053. [Abstract] [Full Text] [PDF] J. V. Lopes, J. M. Pacheco, and D. Dingli Acquired hematopoietic stem-cell disorders and mammalian size Blood, December 1, 2007; 110(12): 4120 - 4122. [Abstract] [Full Text] [PDF] D. Dingli and J. M Pacheco Ontogenic growth of the haemopoietic stem cell pool in humans Proc R Soc B, October 7, 2007; 274(1624): 2497 - 2501. [Abstract] [Full Text] [PDF] B. E. Shepherd, H.-P. Kiem, P. M. Lansdorp, C. E. Dunbar, G. Aubert, A. LaRochelle, R. Seggewiss, P. Guttorp, and J. L. Abkowitz Hematopoietic stem-cell behavior in nonhuman primates Blood, September 15, 2007; 110(6): 1806 - 1813. [Abstract] [Full Text] [PDF] J. H. Lee, S. G. Kang, and C. H. Kim FoxP3+ T Cells Undergo Conventional First Switch to Lymphoid Tissue Homing Receptors in Thymus but Accelerated Second Switch to Nonlymphoid Tissue Homing Receptors in Secondary Lymphoid Tissues J. Immunol., January 1, 2007; 178(1): 301 - 311. [Abstract] [Full Text] [PDF] J. Chen, A. Larochelle, S. Fricker, G. Bridger, C. E. Dunbar, and J. L. Abkowitz Mobilization as a preparative regimen for hematopoietic stem cell transplantation Blood, May 1, 2006; 107(9): 3764 - 3771. [Abstract] [Full Text] [PDF] A. Larochelle, C. L. Perez, A. Krouse, M. Metzger, S. Fricker, G. Bridger, D. Orlic, R. E. Donahue, J. L. Abkowitz, and C. E. Dunbar Mobilization as a Preparative Regimen for Hematopoietic Stem Cell (HSC) Transplantation in Rhesus Macaques. Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 1709 - 1709. [Abstract] C. E. Murry, L. J. Field, and P. Menasche Cell-Based Cardiac Repair: Reflections at the 10-Year Point Circulation, November 15, 2005; 112(20): 3174 - 3183. [Full Text] [PDF] S. N. Catlin, P. Guttorp, and J. L. Abkowitz The kinetics of clonal dominance in myeloproliferative disorders Blood, October 15, 2005; 106(8): 2688 - 2692. [Abstract] [Full Text] [PDF] R. Hu, G. L. Mukhina, S. Piantadosi, J. P. Barber, R. J. Jones, and R. A. Brodsky PIG-A mutations in normal hematopoiesis Blood, May 15, 2005; 105(10): 3848 - 3854. [Abstract] [Full Text] [PDF] T. Ueda, S. Brenner, H. L. Malech, S. M. Langemeijer, S. Perl, M. Kirby, O. A. Phang, A. E. Krouse, R. E. Donahue, E. M. Kang, et al. Cloning and Functional Analysis of the Rhesus Macaque ABCG2 Gene: FORCED EXPRESSION CONFERS AN SP PHENOTYPE AMONG HEMATOPOIETIC STEM CELL PROGENY IN VIVO J. Biol. Chem., January 14, 2005; 280(2): 991 - 998. [Abstract] [Full Text] [PDF] J. L. Abkowitz, A. E. Robinson, S. Kale, M. W. Long, and J. Chen Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure Blood, August 15, 2003; 102(4): 1249 - 1253. [Abstract] [Full Text] [PDF] K. F. McCarthy Marrow frequency of rat long-term repopulating cells: evidence that marrow hematopoietic stem cell concentration may be inversely proportional to species body weight Blood, May 1, 2003; 101(9): 3431 - 3435. [Abstract] [Full Text] [PDF] C. Baum, J. Dullmann, Z. Li, B. Fehse, J. Meyer, D. A. Williams, and C. von Kalle Side effects of retroviral gene transfer into hematopoietic stem cells Blood, March 15, 2003; 101(6): 2099 - 2113. [Abstract] [Full Text] [PDF] M. Y. Gordon, J. L. Lewis, and S. B. Marley Of mice and men ... and elephants Blood, December 15, 2002; 100(13): 4679 - 4679. [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020