SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on June 14, 2002; DOI 10.1182/blood-2002-03-0892. This Article Full Text (PDF) All Versions of this Article: 2002-03-0892v1 100/7/2289    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rawstron, A. C Articles by Houlston, R. S Search for Related Content PubMed PubMed Citation Articles by Rawstron, A. C Articles by Houlston, R. S Social Bookmarking                   What's this? Submitted April 2, 2002 Accepted May 2, 2002 Inherited predisposition to CLL is detectable as sub-clinical monoclonal B-lymphocyte expansion Andy C Rawstron, Martin R Yuille, Julie Fuller, Matthew Cullen, Ben Kennedy, Stephen J Richards, Andrew S Jack, Estella Matutes, Daniel Catovsky, Peter Hillmen, and Richard S Houlston* Academic Unit of Haematology and Oncology, University of Leeds, Leeds, West Yorkshire, United Kingdom Academic Department of Haematology and Cytogenetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom * Corresponding author; email: r.houlston{at}icr.ac.uk. Monoclonal CLL-phenotype cells are detectable in 3.5% of otherwise normal individuals using flow cytometric analysis of CD5/CD20/CD79b expression on CD19-gated B-cells. To determine whether detection of such CLL-phenotype cells is indicative of an inherited predisposition, we examined 59 healthy first-degree relatives of patients from 21 CLL families. CLL-phenotype cells were detected in 8/59 relatives (13.5%), representing a highly significant increase in risk (p=0.00002). CLL-phenotype cell levels were stable with time, and had the characteristics of indolent CLL. Both indolent and aggressive clinical forms were found in family members, suggesting that initiation and proliferation involves distinct factors. The detection of CLL-phenotype cells provides a surrogate marker of carrier status, potentially facilitating gene identification through mapping in families and direct analysis of isolated CLL-phenotype cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: I. D. Giudice, F. R. Mauro, M. S. De Propris, I. D. Starza, D. Armiento, A. P. Iori, G. F. Torelli, A. Guarini, and R. Foa Identification of monoclonal B-cell lymphocytosis among sibling transplant donors for chronic lymphocytic leukemia patients Blood, September 24, 2009; 114(13): 2848 - 2849. [Full Text] [PDF] A. Dagklis, C. Fazi, C. Sala, V. Cantarelli, C. Scielzo, R. Massacane, D. Toniolo, F. Caligaris-Cappio, K. Stamatopoulos, and P. Ghia The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring Blood, July 2, 2009; 114(1): 26 - 32. [Abstract] [Full Text] [PDF] L. R. Goldin, M. Bjorkholm, S. Y. Kristinsson, I. Turesson, and O. Landgren Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia Haematologica, May 1, 2009; 94(5): 647 - 653. [Abstract] [Full Text] [PDF] F. Caligaris-Cappio and P. Ghia Novel Insights in Chronic Lymphocytic Leukemia: Are We Getting Closer to Understanding the Pathogenesis of the Disease? J. Clin. Oncol., September 20, 2008; 26(27): 4497 - 4503. [Abstract] [Full Text] [PDF] A. C. Rawstron, F. L. Bennett, S. J.M. O'Connor, M. Kwok, J. A.L. Fenton, M. Plummer, R. de Tute, R. G. Owen, S. J. Richards, A. S. Jack, et al. Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia N. Engl. J. Med., August 7, 2008; 359(6): 575 - 583. [Abstract] [Full Text] [PDF] D. Crowther-Swanepoel, R. Wild, G. Sellick, M. J. S. Dyer, F. R. Mauro, R. J. G. Cuthbert, V. Jonsson, E. Matutes, C. Dearden, J. Wiley, et al. Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL Blood, June 15, 2008; 111(12): 5691 - 5693. [Abstract] [Full Text] [PDF] G. S. Sellick, L. R. Goldin, R. W. Wild, S. L. Slager, L. Ressenti, S. S. Strom, M. J. S. Dyer, F. R. Mauro, G. E. Marti, S. Fuller, et al. A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia Blood, November 1, 2007; 110(9): 3326 - 3333. [Abstract] [Full Text] [PDF] D. Ng, O. Toure, M.-H. Wei, D. C. Arthur, F. Abbasi, L. Fontaine, G. E. Marti, J. F. Fraumeni Jr, L. R. Goldin, N. Caporaso, et al. Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia Blood, February 1, 2007; 109(3): 916 - 925. [Abstract] [Full Text] [PDF] L. R. Goldin and S. L. Slager Familial CLL: Genes and Environment Hematology, January 1, 2007; 2007(1): 339 - 345. [Abstract] [Full Text] [PDF] K. W. L. Yee and S. M. O'Brien Chronic Lymphocytic Leukemia: Diagnosis and Treatment Mayo Clin. Proc., August 1, 2006; 81(8): 1105 - 1129. [Abstract] [Full Text] [PDF] E. Montserrat, C. Moreno, J. Esteve, A. Urbano-Ispizua, E. Gine, and F. Bosch How I treat refractory CLL Blood, February 15, 2006; 107(4): 1276 - 1283. [Abstract] [Full Text] [PDF] J. Starczynski, C. Pepper, G. Pratt, L. Hooper, A. Thomas, D. Milligan, P. Bentley, and C. Fegan Common Polymorphism G(-248)A in the Promoter Region of the bax Gene Results in Significantly Shorter Survival in Patients With Chronic Lymphocytic Leukemia Once Treatment Is Initiated J. Clin. Oncol., March 1, 2005; 23(7): 1514 - 1521. [Abstract] [Full Text] [PDF] N. Chiorazzi, K. R. Rai, and M. Ferrarini Chronic Lymphocytic Leukemia N. Engl. J. Med., February 24, 2005; 352(8): 804 - 815. [Full Text] [PDF] L. R. Goldin, R. M. Pfeiffer, X. Li, and K. Hemminki Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database Blood, September 15, 2004; 104(6): 1850 - 1854. [Abstract] [Full Text] [PDF] P. Ghia, G. Prato, C. Scielzo, S. Stella, M. Geuna, G. Guida, and F. Caligaris-Cappio Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly Blood, March 15, 2004; 103(6): 2337 - 2342. [Abstract] [Full Text] [PDF] M. J. Keating, N. Chiorazzi, B. Messmer, R. N. Damle, S. L. Allen, K. R. Rai, M. Ferrarini, and T. J. Kipps Biology and Treatment of Chronic Lymphocytic Leukemia Hematology, January 1, 2003; 2003(1): 153 - 175. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020