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Prepublished online as a Blood First Edition Paper on August 15, 2002; DOI 10.1182/blood-2002-03-0894. This Article Full Text (PDF) All Versions of this Article: 2002-03-0894v1 101/1/292    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Philippoussis, F. Articles by Hugo, P. Search for Related Content PubMed PubMed Citation Articles by Philippoussis, F. Articles by Hugo, P. Social Bookmarking                   What's this? Submitted March 21, 2002 Accepted July 31, 2002 Monoglycerides induce apoptosis in human leukemic cells while sparing normal peripheral blood mononuclear cells Fabianne Philippoussis, Chantal Arguin, Veronique Mateo, Ann-Muriel Steff*, and Patrice Hugo PROCREA BioSciences, Montreal, PQ, Canada; Department of Microbiology and Immunology, McGill University, Montreal, PQ, Canada PROCREA BioSciences, Montreal, PQ, Canada Laboratoire d'allegie, Centre de Recherches du CHUM, University of Montreal, Montreal, PQ, Canada * Corresponding author; email: asteff{at}procrea.qc.ca. A major drawback of the current anti-neoplastic treatments is their lack of specificity towards cancer cells, as they are most often cytotoxic to normal cells, thus creating related side effects. Hence, the identification of new apoptosis-inducing agents, specifically targeting malignant cells while sparing their normal counterparts, is of crucial interest. We show here that monoglycerides, a family of lipids consisting of a single fatty acid attached to a glycerol backbone, induce cell death in several human leukemic cell lines. Importantly, treatment of primary leukemic cells, obtained from B-cell chronic lymphocytic leukemia patients, resulted in rapid apoptosis. In striking contrast, resting or activated human peripheral blood mononuclear cells from healthy individuals were resistant to the same treatment. Therefore, these compounds could represent potential anti-leukemic drugs or could allow for the design of novel therapeutic agents applied to leukemia. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. T. Jones, E. Addison, J. M. North, M. W. Lowdell, A. V. Hoffbrand, A. B. Mehta, K. Ganeshaguru, N. I. Folarin, and R. G. Wickremasinghe Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs Blood, March 1, 2004; 103(5): 1855 - 1861. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020