SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on December 27, 2002; DOI 10.1182/blood-2002-03-0947. This Article Full Text (PDF) All Versions of this Article: 2002-03-0947v1 101/9/3386    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Matsushima, T. Articles by Murakami, H. Search for Related Content PubMed PubMed Citation Articles by Matsushima, T. Articles by Murakami, H. Social Bookmarking                   What's this? Submitted March 27, 2002 Accepted December 12, 2002 Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia Takafumi Matsushima*, Hiroshi Handa, Akihiko Yokohama, Jun Nagasaki, Hiromi Koiso, Yoshitora Kin, Yoko Tanaka, Tohru Sakura, Norifumi Tsukamoto, Masamitsu Karasawa, Katsuhiko Itoh, Hisami Hirabayashi, Morio Sawamura, Shogo Shinonome, Shun-ichi Shimano, Shuichi Miyawaki, Yoshihisa Nojima, and Hirokazu Murakami Third Department of Internal Medicine, Gunma University, Maebashi, Japan Department of Internal Medicine, National Nishigunma Hospital, Shibukawa, Japan Department of Internal Medicine, Fujioka General Hospital, Fujioka, Japan Department of Internal Medicine, Fukaya Red Cross Hospital, Fukaya, Japan Department of Internal Medicine, Gunma Cancer Center, Ohta, Japan Division of Hematology, Saiseikai Maebashi Hospital, Maebashi, Japan Division of Blood Transfusion Service, Gunma University Hospital, Maebashi, Japan Department of Internal Medicine, National Takasaki Hospital, Takasaki, Japan School of Health Sciences, Faculty of Medicine, Gunma University, Maebashi, Japan * Corresponding author; email: tmatsu{at}showa.gunma-u.ac.jp. By retrospectively analyzing 288 patients with de novo myelodysplastic syndrome (MDS), we sought to determine the prevalence and clinical characteristics of bone marrow eosinophilia and basophilia that were detected at presentation. Bone marrow eosinophilia and basophilia were defined as a differential count of each cell type exceeding 5.0% and 1.0%, respectively. Thirty-six out of 288 MDS patients (12.8%) fulfilled this criterion for bone marrow eosinophilia (MDS-Eos). Thirty-four patients (11.8%) showed basophilia (MDS-Bas), and 11 (3.8%) satisfied both criteria (MDS-EosBas). The remaining 229 patients had neither eosinophilia nor basophilia in their bone marrow (MDS-/-) at presentation. Cytogenetic analysis was carried out on unstimulated bone marrow cells obtained from 264 patients. When the cytogenetic categorization of the IPSS (International Prognostic Scoring System) for MDS was applied, significantly higher numbers of MDS-Eos and MDS-Bas patients had chromosomal abnormalities carrying intermediate or poor prognosis, compared with the MDS-/- patients. Specific chromosomal abnormalities and complex karyotypes were associated with MDS-Eos and/or MDS-Bas. In accordance with these results, the overall survival rate was significantly lower and the evolution to acute myelogenous leukemia (AML) occurred more frequently in the MDS-Eos and MDS-Bas than the MDS-/- patients. Multivariate analysis demonstrated that bone marrow basophilia was an independent risk factor for evolution to AML. Our study indicates that bone marrow eosinophilia and basophilia in MDS patients predict a poorer prognosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Matsuda, U. Germing, I. Jinnai, M. Misumi, A. Kuendgen, S. Knipp, M. Aivado, M. Iwanaga, Y. Miyazaki, H. Tsushima, et al. Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes Blood, October 15, 2005; 106(8): 2633 - 2640. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020