SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on June 21, 2002; DOI 10.1182/blood-2002-04-1149. This Article Full Text (PDF) All Versions of this Article: 2002-04-1149v1 100/8/2692    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bokoch, G. M Articles by Diebold, B. A Search for Related Content PubMed PubMed Citation Articles by Bokoch, G. M Articles by Diebold, B. A Social Bookmarking                   What's this? Submitted April 16, 2002 Accepted June 4, 2002 Current molecular models for NADPH oxidase regulation by Rac GTPase Gary M Bokoch* and Becky A Diebold Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA * Corresponding author; email: bokoch{at}scripps.edu. Reactive oxygen species (ROS) have been increasingly recognized as important components of cell signaling, in addition to their well-established roles in host defense. The formation of ROS in phagocytic- and nonphagocytic cells involves membrane-localized and Rac GTPase-regulated NADPH oxidase(s). We discuss here the current molecular models for Rac GTPase action in the control of the phagocytic leukocyte NADPH oxidase. As a mechanistically detailed example of Rac GTPase signaling, the NADPH oxidase provides a potential paradigm for signaling by Rho family GTPases in general. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Ueyama, T. Kusakabe, S. Karasawa, T. Kawasaki, A. Shimizu, J. Son, T. L. Leto, A. Miyawaki, and N. Saito Sequential Binding of Cytosolic Phox Complex to Phagosomes through Regulated Adaptor Proteins: Evaluation Using the Novel Monomeric Kusabira-Green System and Live Imaging of Phagocytosis J. Immunol., July 1, 2008; 181(1): 629 - 640. [Abstract] [Full Text] [PDF] W. M. Nauseef Biological Roles for the NOX Family NADPH Oxidases J. Biol. Chem., June 20, 2008; 283(25): 16961 - 16965. [Full Text] [PDF] Y.-Y. Kao, D. Gianni, B. Bohl, R. M. Taylor, and G. M. Bokoch Identification of a Conserved Rac-binding Site on NADPH Oxidases Supports a Direct GTPase Regulatory Mechanism J. Biol. Chem., May 9, 2008; 283(19): 12736 - 12746. [Abstract] [Full Text] [PDF] W. Han, H. Li, V. A. M. Villar, A. M. Pascua, M. I. Dajani, X. Wang, A. Natarajan, M. T. Quinn, R. A. Felder, P. A. Jose, et al. Lipid Rafts Keep NADPH Oxidase in the Inactive State in Human Renal Proximal Tubule Cells Hypertension, February 1, 2008; 51(2): 481 - 487. [Abstract] [Full Text] [PDF] S. A. Cooper, A. Whaley-Connell, J. Habibi, Y. Wei, G. Lastra, C. Manrique, S. Stas, and J. R. Sowers Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2009 - H2023. [Abstract] [Full Text] [PDF] Hardev Ramandeep Singh Girn, S. Ahilathirunayagam, A. I. D. Mavor, and S. Homer-Vanniasinkam Reperfusion Syndrome: Cellular Mechanisms of Microvascular Dysfunction and Potential Therapeutic Strategies Vascular and Endovascular Surgery, September 1, 2007; 41(4): 277 - 293. [Abstract] [PDF] X. Chen, T. D. Abair, M. R. Ibanez, Y. Su, M. R. Frey, R. S. Dise, D. B. Polk, A. B. Singh, R. C. Harris, R. Zent, et al. Integrin {alpha}1{beta}1 Controls Reactive Oxygen Species Synthesis by Negatively Regulating Epidermal Growth Factor Receptor-Mediated Rac Activation Mol. Cell. Biol., May 1, 2007; 27(9): 3313 - 3326. [Abstract] [Full Text] [PDF] X.-P. Gao, X. Zhu, J. Fu, Q. Liu, R. S. Frey, and A. B. Malik Blockade of Class IA Phosphoinositide 3-Kinase in Neutrophils Prevents NADPH Oxidase Activation- and Adhesion-dependent Inflammation J. Biol. Chem., March 2, 2007; 282(9): 6116 - 6125. [Abstract] [Full Text] [PDF] T. Ueyama, T. Tatsuno, T. Kawasaki, S. Tsujibe, Y. Shirai, H. Sumimoto, T. L. Leto, and N. Saito A Regulated Adaptor Function of p40phox: Distinct p67phox Membrane Targeting by p40phox and by p47phox Mol. Biol. Cell, February 1, 2007; 18(2): 441 - 454. [Abstract] [Full Text] [PDF] K. Bedard and K.-H. Krause The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology Physiol Rev, January 1, 2007; 87(1): 245 - 313. [Abstract] [Full Text] [PDF] E.-J. Chang, H. J. Kim, J. Ha, H. J. Kim, J. Ryu, K.-H. Park, U.-H. Kim, Z. H. Lee, H.-M. Kim, D. E. Fisher, et al. Hyaluronan inhibits osteoclast differentiation via Toll-like receptor 4 J. Cell Sci., January 1, 2007; 120(1): 166 - 176. [Abstract] [Full Text] [PDF] C. Carter, R. Healy, N. M. O'Tool, S.M. S. Naqvi, G. Ren, S. Park, G. A. Beattie, H. T. Horner, and R. W. Thornburg Tobacco Nectaries Express a Novel NADPH Oxidase Implicated in the Defense of Floral Reproductive Tissues against Microorganisms Plant Physiology, January 1, 2007; 143(1): 389 - 399. [Abstract] [Full Text] [PDF] A. Utomo, X. Cullere, M. Glogauer, W. Swat, and T. N. Mayadas Vav Proteins in Neutrophils Are Required for Fc{gamma}R-Mediated Signaling to Rac GTPases and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Component p40(phox) J. Immunol., November 1, 2006; 177(9): 6388 - 6397. [Abstract] [Full Text] [PDF] C. Hidalgo, G. Sanchez, G. Barrientos, and P. Aracena-Parks A Transverse Tubule NADPH Oxidase Activity Stimulates Calcium Release from Isolated Triads via Ryanodine Receptor Type 1 S -Glutathionylation J. Biol. Chem., September 8, 2006; 281(36): 26473 - 26482. [Abstract] [Full Text] [PDF] R. Reinehr, S. Becker, J. Braun, A. Eberle, S. Grether-Beck, and D. Haussinger Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis J. Biol. Chem., August 11, 2006; 281(32): 23150 - 23166. [Abstract] [Full Text] [PDF] R. Kohl, S. Preiss, A. von Knethen, and B. Brune Oxidized low-density lipoprotein depletes PKC{alpha} and attenuates reactive oxygen species formation in monocytes/macrophages Cardiovasc Res, August 1, 2006; 71(3): 574 - 585. [Abstract] [Full Text] [PDF] L. P. Ganesan, T. Joshi, H. Fang, V. K. Kutala, J. Roda, R. Trotta, A. Lehman, P. Kuppusamy, J. C. Byrd, W. E. Carson, et al. Fc{gamma}R-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways Blood, July 15, 2006; 108(2): 718 - 725. [Abstract] [Full Text] [PDF] F. Custodis, M. Eberl, H. Kilter, M. Bohm, and U. Laufs Association of RhoGDI{alpha} with Rac1 GTPase mediates free radical production during myocardial hypertrophy Cardiovasc Res, July 15, 2006; 71(2): 342 - 351. [Abstract] [Full Text] [PDF] S.-L. Liang, H. Liu, and A. Zhou Lovastatin-Induced Apoptosis in Macrophages through the Rac1/Cdc42/JNK Pathway J. Immunol., July 1, 2006; 177(1): 651 - 656. [Abstract] [Full Text] [PDF] A. Mizrahi, Y. Berdichevsky, Y. Ugolev, S. Molshanski-Mor, Y. Nakash, I. Dahan, N. Alloul, Y. Gorzalczany, R. Sarfstein, M. Hirshberg, et al. Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships J. Leukoc. Biol., May 1, 2006; 79(5): 881 - 895. [Abstract] [Full Text] [PDF] A. M. Condliffe, L. M. C. Webb, G. J. Ferguson, K. Davidson, M. Turner, E. Vigorito, M. Manifava, E. R. Chilvers, L. R. Stephens, and P. T. Hawkins RhoG Regulates the Neutrophil NADPH Oxidase J. Immunol., May 1, 2006; 176(9): 5314 - 5320. [Abstract] [Full Text] [PDF] E. Cernuda-Morollon and A. J. Ridley Rho GTPases and Leukocyte Adhesion Receptor Expression and Function in Endothelial Cells Circ. Res., March 31, 2006; 98(6): 757 - 767. [Abstract] [Full Text] [PDF] P. L. Hordijk Regulation of NADPH Oxidases: The Role of Rac Proteins Circ. Res., March 3, 2006; 98(4): 453 - 462. [Abstract] [Full Text] [PDF] W. J. O'Brien, C. Krema, T. Heimann, and H. Zhao Expression of NADPH oxidase in rabbit corneal epithelial and stromal cells in culture. Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 853 - 863. [Abstract] [Full Text] [PDF] T. Ueyama, M. Geiszt, and T. L. Leto Involvement of rac1 in activation of multicomponent nox1- and nox3-based NADPH oxidases. Mol. Cell. Biol., March 1, 2006; 26(6): 2160 - 2174. [Abstract] [Full Text] [PDF] E. Gulbins and P. L. Li Physiological and pathophysiological aspects of ceramide Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R11 - R26. [Abstract] [Full Text] [PDF] A. S. Kamiguti, L. Serrander, K. Lin, R. J. Harris, J. C. Cawley, D. J. Allsup, J. R. Slupsky, K.-H. Krause, and M. Zuzel Expression and Activity of NOX5 in the Circulating Malignant B Cells of Hairy Cell Leukemia J. Immunol., December 15, 2005; 175(12): 8424 - 8430. [Abstract] [Full Text] [PDF] A. Jinnouchi, Y. Aida, K. Nozoe, K. Maeda, and M. J. Pabst Local anesthetics inhibit priming of neutrophils by lipopolysaccharide for enhanced release of superoxide: suppression of cytochrome b558 expression by disparate mechanisms J. Leukoc. Biol., December 1, 2005; 78(6): 1356 - 1365. [Abstract] [Full Text] [PDF] C. Guichard, E. Pedruzzi, C. Dewas, M. Fay, C. Pouzet, M. Bens, A. Vandewalle, E. Ogier-Denis, M.-A. Gougerot-Pocidalo, and C. Elbim Interleukin-8-induced Priming of Neutrophil Oxidative Burst Requires Sequential Recruitment of NADPH Oxidase Components into Lipid Rafts J. Biol. Chem., November 4, 2005; 280(44): 37021 - 37032. [Abstract] [Full Text] [PDF] S. Groth, M. Schulze, H. Kalthoff, F. Fandrich, and H. Ungefroren Adhesion and Rac1-dependent Regulation of Biglycan Gene Expression by Transforming Growth Factor-{beta}: EVIDENCE FOR OXIDATIVE SIGNALING THROUGH NADPH OXIDASE J. Biol. Chem., September 30, 2005; 280(39): 33190 - 33199. [Abstract] [Full Text] [PDF] T. Kawahara, D. Ritsick, G. Cheng, and J. D. Lambeth Point Mutations in the Proline-rich Region of p22phox Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen Generation J. Biol. Chem., September 9, 2005; 280(36): 31859 - 31869. [Abstract] [Full Text] [PDF] J. M. Davis, S. B. Rasmussen, and A. D. O'Brien Cytotoxic Necrotizing Factor Type 1 Production by Uropathogenic Escherichia coli Modulates Polymorphonuclear Leukocyte Function Infect. Immun., September 1, 2005; 73(9): 5301 - 5310. [Abstract] [Full Text] [PDF] A. Pines, L. Perrone, N. Bivi, M. Romanello, G. Damante, M. Gulisano, M. R. Kelley, F. Quadrifoglio, and G. Tell Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP Nucleic Acids Res., August 2, 2005; 33(14): 4379 - 4394. [Abstract] [Full Text] [PDF] R. Reinehr, S. Becker, A. Eberle, S. Grether-Beck, and D. Haussinger Involvement of NADPH Oxidase Isoforms and Src Family Kinases in CD95-dependent Hepatocyte Apoptosis J. Biol. Chem., July 22, 2005; 280(29): 27179 - 27194. [Abstract] [Full Text] [PDF] T. Zhao and G. M. Bokoch Critical Role of Proline-Rich Tyrosine Kinase 2 in Reversion of the Adhesion-Mediated Suppression of Reactive Oxygen Species Generation by Human Neutrophils J. Immunol., June 15, 2005; 174(12): 8049 - 8055. [Abstract] [Full Text] [PDF] U. Laufs and M. Bohm Cardiac effects of statins-advancements and open questions Cardiovasc Res, June 1, 2005; 66(3): 427 - 429. [Full Text] [PDF] S. J. Klebanoff Myeloperoxidase: friend and foe J. Leukoc. Biol., May 1, 2005; 77(5): 598 - 625. [Abstract] [Full Text] [PDF] D. Carstanjen, A. Yamauchi, A. Koornneef, H. Zang, M.-D. Filippi, C. Harris, J. Towe, S. Atkinson, Y. Zheng, M. C. Dinauer, et al. Rac2 Regulates Neutrophil Chemotaxis, Superoxide Production, and Myeloid Colony Formation through Multiple Distinct Effector Pathways J. Immunol., April 15, 2005; 174(8): 4613 - 4620. [Abstract] [Full Text] [PDF] A. von Knethen, A. Tautenhahn, H. Link, D. Lindemann, and B. Brune Activation-Induced Depletion of Protein Kinase C{alpha} Provokes Desensitization of Monocytes/Macrophages in Sepsis J. Immunol., April 15, 2005; 174(8): 4960 - 4965. [Abstract] [Full Text] [PDF] U. Laufs, S. Wassmann, T. Czech, T. Munzel, M. Eisenhauer, M. Bohm, and G. Nickenig Physical Inactivity Increases Oxidative Stress, Endothelial Dysfunction, and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., April 1, 2005; 25(4): 809 - 814. [Abstract] [Full Text] [PDF] L. Cheng, W. Cao, J. Behar, P. Biancani, and K. M. Harnett Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle Am J Physiol Gastrointest Liver Physiol, April 1, 2005; 288(4): G787 - G797. [Abstract] [Full Text] [PDF] K. A. Gauss, P. L. Bunger, T. C. Larson, C. J. Young, L. K. Nelson-Overton, D. W. Siemsen, and M. T. Quinn Identification of a novel tumor necrosis factor {alpha}-responsive region in the NCF2 promoter J. Leukoc. Biol., February 1, 2005; 77(2): 267 - 278. [Abstract] [Full Text] [PDF] J. H. Seo, Y. Ahn, S.-R. Lee, C. Y. Yeo, and K. C. Hur The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway Mol. Biol. Cell, January 1, 2005; 16(1): 348 - 357. [Abstract] [Full Text] [PDF] R. P. Brandes and J. Kreuzer Vascular NADPH oxidases: molecular mechanisms of activation Cardiovasc Res, January 1, 2005; 65(1): 16 - 27. [Abstract] [Full Text] [PDF] K.-P. Chuang, Y.-F. Huang, Y.-L. Hsu, H.-S. Liu, H.-C. Chen, and C.-C. Shieh Ligation of lymphocyte function-associated antigen-1 on monocytes decreases very late antigen-4-mediated adhesion through a reactive oxygen species-dependent pathway Blood, December 15, 2004; 104(13): 4046 - 4053. [Abstract] [Full Text] [PDF]