|
|
Prepublished online as a Blood First Edition Paper on June 21, 2002; DOI 10.1182/blood-2002-04-1149.

Submitted April 16, 2002
Accepted June 4, 2002
Current molecular models for NADPH oxidase regulation by Rac GTPase
Gary M Bokoch* and Becky A Diebold
Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
* Corresponding author; email: bokoch{at}scripps.edu.
Reactive oxygen species (ROS) have been increasingly recognized as important components of cell signaling, in addition to their well-established roles in host defense. The formation of ROS in phagocytic- and nonphagocytic cells involves membrane-localized and Rac GTPase-regulated NADPH oxidase(s). We discuss here the current molecular models for Rac GTPase action in the control of the phagocytic leukocyte NADPH oxidase. As a mechanistically detailed example of Rac GTPase signaling, the NADPH oxidase provides a potential paradigm for signaling by Rho family GTPases in general.

CiteULike Connotea Del.icio.us Digg Reddit Technorati What's this?
This article has been cited by other articles:

|
 |

|
 |
 
E. Monaghan-Benson and K. Burridge
The Regulation of Vascular Endothelial Growth Factor-induced Microvascular Permeability Requires Rac and Reactive Oxygen Species
J. Biol. Chem.,
September 18, 2009;
284(38):
25602 - 25611.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Gianni, B. Diaz, N. Taulet, B. Fowler, S. A. Courtneidge, and G. M. Bokoch
Novel p47phox-Related Organizers Regulate Localized NADPH Oxidase 1 (Nox1) Activity
Sci. Signal.,
September 15, 2009;
2(88):
ra54 - ra54.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. E. Keith, D. W. Hynes, J. E. Sholdice, and M. A. Valvano
Delayed association of the NADPH oxidase complex with macrophage vacuoles containing the opportunistic pathogen Burkholderia cenocepacia
Microbiology,
April 1, 2009;
155(4):
1004 - 1015.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Brechard and E. J. Tschirhart
Regulation of superoxide production in neutrophils: role of calcium influx
J. Leukoc. Biol.,
November 1, 2008;
84(5):
1223 - 1237.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Ueyama, T. Kusakabe, S. Karasawa, T. Kawasaki, A. Shimizu, J. Son, T. L. Leto, A. Miyawaki, and N. Saito
Sequential Binding of Cytosolic Phox Complex to Phagosomes through Regulated Adaptor Proteins: Evaluation Using the Novel Monomeric Kusabira-Green System and Live Imaging of Phagocytosis
J. Immunol.,
July 1, 2008;
181(1):
629 - 640.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. M. Nauseef
Biological Roles for the NOX Family NADPH Oxidases
J. Biol. Chem.,
June 20, 2008;
283(25):
16961 - 16965.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y.-Y. Kao, D. Gianni, B. Bohl, R. M. Taylor, and G. M. Bokoch
Identification of a Conserved Rac-binding Site on NADPH Oxidases Supports a Direct GTPase Regulatory Mechanism
J. Biol. Chem.,
May 9, 2008;
283(19):
12736 - 12746.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. Han, H. Li, V. A. M. Villar, A. M. Pascua, M. I. Dajani, X. Wang, A. Natarajan, M. T. Quinn, R. A. Felder, P. A. Jose, et al.
Lipid Rafts Keep NADPH Oxidase in the Inactive State in Human Renal Proximal Tubule Cells
Hypertension,
February 1, 2008;
51(2):
481 - 487.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. A. Cooper, A. Whaley-Connell, J. Habibi, Y. Wei, G. Lastra, C. Manrique, S. Stas, and J. R. Sowers
Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance
Am J Physiol Heart Circ Physiol,
October 1, 2007;
293(4):
H2009 - H2023.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Hardev Ramandeep Singh Girn, S. Ahilathirunayagam, A. I. D. Mavor, and S. Homer-Vanniasinkam
Reperfusion Syndrome: Cellular Mechanisms of Microvascular Dysfunction and Potential Therapeutic Strategies
Vascular and Endovascular Surgery,
September 1, 2007;
41(4):
277 - 293.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
X. Chen, T. D. Abair, M. R. Ibanez, Y. Su, M. R. Frey, R. S. Dise, D. B. Polk, A. B. Singh, R. C. Harris, R. Zent, et al.
Integrin {alpha}1{beta}1 Controls Reactive Oxygen Species Synthesis by Negatively Regulating Epidermal Growth Factor Receptor-Mediated Rac Activation
Mol. Cell. Biol.,
May 1, 2007;
27(9):
3313 - 3326.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
X.-P. Gao, X. Zhu, J. Fu, Q. Liu, R. S. Frey, and A. B. Malik
Blockade of Class IA Phosphoinositide 3-Kinase in Neutrophils Prevents NADPH Oxidase Activation- and Adhesion-dependent Inflammation
J. Biol. Chem.,
March 2, 2007;
282(9):
6116 - 6125.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Ueyama, T. Tatsuno, T. Kawasaki, S. Tsujibe, Y. Shirai, H. Sumimoto, T. L. Leto, and N. Saito
A Regulated Adaptor Function of p40phox: Distinct p67phox Membrane Targeting by p40phox and by p47phox
Mol. Biol. Cell,
February 1, 2007;
18(2):
441 - 454.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Bedard and K.-H. Krause
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Physiol Rev,
January 1, 2007;
87(1):
245 - 313.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E.-J. Chang, H. J. Kim, J. Ha, H. J. Kim, J. Ryu, K.-H. Park, U.-H. Kim, Z. H. Lee, H.-M. Kim, D. E. Fisher, et al.
Hyaluronan inhibits osteoclast differentiation via Toll-like receptor 4
J. Cell Sci.,
January 1, 2007;
120(1):
166 - 176.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Carter, R. Healy, N. M. O'Tool, S.M. S. Naqvi, G. Ren, S. Park, G. A. Beattie, H. T. Horner, and R. W. Thornburg
Tobacco Nectaries Express a Novel NADPH Oxidase Implicated in the Defense of Floral Reproductive Tissues against Microorganisms
Plant Physiology,
January 1, 2007;
143(1):
389 - 399.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Utomo, X. Cullere, M. Glogauer, W. Swat, and T. N. Mayadas
Vav Proteins in Neutrophils Are Required for Fc{gamma}R-Mediated Signaling to Rac GTPases and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Component p40(phox)
J. Immunol.,
November 1, 2006;
177(9):
6388 - 6397.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Hidalgo, G. Sanchez, G. Barrientos, and P. Aracena-Parks
A Transverse Tubule NADPH Oxidase Activity Stimulates Calcium Release from Isolated Triads via Ryanodine Receptor Type 1 S -Glutathionylation
J. Biol. Chem.,
September 8, 2006;
281(36):
26473 - 26482.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Reinehr, S. Becker, J. Braun, A. Eberle, S. Grether-Beck, and D. Haussinger
Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis
J. Biol. Chem.,
August 11, 2006;
281(32):
23150 - 23166.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Kohl, S. Preiss, A. von Knethen, and B. Brune
Oxidized low-density lipoprotein depletes PKC{alpha} and attenuates reactive oxygen species formation in monocytes/macrophages
Cardiovasc Res,
August 1, 2006;
71(3):
574 - 585.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. P. Ganesan, T. Joshi, H. Fang, V. K. Kutala, J. Roda, R. Trotta, A. Lehman, P. Kuppusamy, J. C. Byrd, W. E. Carson, et al.
Fc{gamma}R-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways
Blood,
July 15, 2006;
108(2):
718 - 725.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. Custodis, M. Eberl, H. Kilter, M. Bohm, and U. Laufs
Association of RhoGDI{alpha} with Rac1 GTPase mediates free radical production during myocardial hypertrophy
Cardiovasc Res,
July 15, 2006;
71(2):
342 - 351.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S.-L. Liang, H. Liu, and A. Zhou
Lovastatin-Induced Apoptosis in Macrophages through the Rac1/Cdc42/JNK Pathway
J. Immunol.,
July 1, 2006;
177(1):
651 - 656.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Mizrahi, Y. Berdichevsky, Y. Ugolev, S. Molshanski-Mor, Y. Nakash, I. Dahan, N. Alloul, Y. Gorzalczany, R. Sarfstein, M. Hirshberg, et al.
Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships
J. Leukoc. Biol.,
May 1, 2006;
79(5):
881 - 895.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. M. Condliffe, L. M. C. Webb, G. J. Ferguson, K. Davidson, M. Turner, E. Vigorito, M. Manifava, E. R. Chilvers, L. R. Stephens, and P. T. Hawkins
RhoG Regulates the Neutrophil NADPH Oxidase
J. Immunol.,
May 1, 2006;
176(9):
5314 - 5320.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Cernuda-Morollon and A. J. Ridley
Rho GTPases and Leukocyte Adhesion Receptor Expression and Function in Endothelial Cells
Circ. Res.,
March 31, 2006;
98(6):
757 - 767.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. L. Hordijk
Regulation of NADPH Oxidases: The Role of Rac Proteins
Circ. Res.,
March 3, 2006;
98(4):
453 - 462.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. J. O'Brien, C. Krema, T. Heimann, and H. Zhao
Expression of NADPH oxidase in rabbit corneal epithelial and stromal cells in culture.
Invest. Ophthalmol. Vis. Sci.,
March 1, 2006;
47(3):
853 - 863.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Ueyama, M. Geiszt, and T. L. Leto
Involvement of rac1 in activation of multicomponent nox1- and nox3-based NADPH oxidases.
Mol. Cell. Biol.,
March 1, 2006;
26(6):
2160 - 2174.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Gulbins and P. L. Li
Physiological and pathophysiological aspects of ceramide
Am J Physiol Regulatory Integrative Comp Physiol,
January 1, 2006;
290(1):
R11 - R26.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. S. Kamiguti, L. Serrander, K. Lin, R. J. Harris, J. C. Cawley, D. J. Allsup, J. R. Slupsky, K.-H. Krause, and M. Zuzel
Expression and Activity of NOX5 in the Circulating Malignant B Cells of Hairy Cell Leukemia
J. Immunol.,
December 15, 2005;
175(12):
8424 - 8430.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Jinnouchi, Y. Aida, K. Nozoe, K. Maeda, and M. J. Pabst
Local anesthetics inhibit priming of neutrophils by lipopolysaccharide for enhanced release of superoxide: suppression of cytochrome b558 expression by disparate mechanisms
J. Leukoc. Biol.,
December 1, 2005;
78(6):
1356 - 1365.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Guichard, E. Pedruzzi, C. Dewas, M. Fay, C. Pouzet, M. Bens, A. Vandewalle, E. Ogier-Denis, M.-A. Gougerot-Pocidalo, and C. Elbim
Interleukin-8-induced Priming of Neutrophil Oxidative Burst Requires Sequential Recruitment of NADPH Oxidase Components into Lipid Rafts
J. Biol. Chem.,
November 4, 2005;
280(44):
37021 - 37032.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Groth, M. Schulze, H. Kalthoff, F. Fandrich, and H. Ungefroren
Adhesion and Rac1-dependent Regulation of Biglycan Gene Expression by Transforming Growth Factor-{beta}: EVIDENCE FOR OXIDATIVE SIGNALING THROUGH NADPH OXIDASE
J. Biol. Chem.,
September 30, 2005;
280(39):
33190 - 33199.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Kawahara, D. Ritsick, G. Cheng, and J. D. Lambeth
Point Mutations in the Proline-rich Region of p22phox Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen Generation
J. Biol. Chem.,
September 9, 2005;
280(36):
31859 - 31869.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. M. Davis, S. B. Rasmussen, and A. D. O'Brien
Cytotoxic Necrotizing Factor Type 1 Production by Uropathogenic Escherichia coli Modulates Polymorphonuclear Leukocyte Function
Infect. Immun.,
September 1, 2005;
73(9):
5301 - 5310.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Pines, L. Perrone, N. Bivi, M. Romanello, G. Damante, M. Gulisano, M. R. Kelley, F. Quadrifoglio, and G. Tell
Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
Nucleic Acids Res.,
August 2, 2005;
33(14):
4379 - 4394.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Reinehr, S. Becker, A. Eberle, S. Grether-Beck, and D. Haussinger
Involvement of NADPH Oxidase Isoforms and Src Family Kinases in CD95-dependent Hepatocyte Apoptosis
J. Biol. Chem.,
July 22, 2005;
280(29):
27179 - 27194.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Zhao and G. M. Bokoch
Critical Role of Proline-Rich Tyrosine Kinase 2 in Reversion of the Adhesion-Mediated Suppression of Reactive Oxygen Species Generation by Human Neutrophils
J. Immunol.,
June 15, 2005;
174(12):
8049 - 8055.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
U. Laufs and M. Bohm
Cardiac effects of statins-advancements and open questions
Cardiovasc Res,
June 1, 2005;
66(3):
427 - 429.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Carstanjen, A. Yamauchi, A. Koornneef, H. Zang, M.-D. Filippi, C. Harris, J. Towe, S. Atkinson, Y. Zheng, M. C. Dinauer, et al.
Rac2 Regulates Neutrophil Chemotaxis, Superoxide Production, and Myeloid Colony Formation through Multiple Distinct Effector Pathways
J. Immunol.,
April 15, 2005;
174(8):
4613 - 4620.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. von Knethen, A. Tautenhahn, H. Link, D. Lindemann, and B. Brune
Activation-Induced Depletion of Protein Kinase C{alpha} Provokes Desensitization of Monocytes/Macrophages in Sepsis
J. Immunol.,
April 15, 2005;
174(8):
4960 - 4965.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
U. Laufs, S. Wassmann, T. Czech, T. Munzel, M. Eisenhauer, M. Bohm, and G. Nickenig
Physical Inactivity Increases Oxidative Stress, Endothelial Dysfunction, and Atherosclerosis
Arterioscler Thromb Vasc Biol,
April 1, 2005;
25(4):
809 - 814.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. Cheng, W. Cao, J. Behar, P. Biancani, and K. M. Harnett
Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle
Am J Physiol Gastrointest Liver Physiol,
April 1, 2005;
288(4):
G787 - G797.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. A. Gauss, P. L. Bunger, T. C. Larson, C. J. Young, L. K. Nelson-Overton, D. W. Siemsen, and M. T. Quinn
Identification of a novel tumor necrosis factor {alpha}-responsive region in the NCF2 promoter
J. Leukoc. Biol.,
February 1, 2005;
77(2):
267 - 278.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. H. Seo, Y. Ahn, S.-R. Lee, C. Y. Yeo, and K. C. Hur
The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway
Mol. Biol. Cell,
January 1, 2005;
16(1):
348 - 357.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. P. Brandes and J. Kreuzer
Vascular NADPH oxidases: molecular mechanisms of activation
Cardiovasc Res,
January 1, 2005;
65(1):
16 - 27.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K.-P. Chuang, Y.-F. Huang, Y.-L. Hsu, H.-S. Liu, H.-C. Chen, and C.-C. Shieh
Ligation of lymphocyte function-associated antigen-1 on monocytes decreases very late antigen-4-mediated adhesion through a reactive oxygen species-dependent pathway
Blood,
December 15, 2004;
104(13):
4046 - 4053.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. A. Swanson and A. D. Hoppe
The coordination of signaling during Fc receptor-mediated phagocytosis
J. Leukoc. Biol.,
December 1, 2004;
76(6):
1093 - 1103.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Patil, M. Bunderson, J. Wilham, and S. M. Black
Important role for Rac1 in regulating reactive oxygen species generation and pulmonary arterial smooth muscle cell growth
Am J Physiol Lung Cell Mol Physiol,
December 1, 2004;
287(6):
L1314 - L1322.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Zhao, A. Wimmer, K. Trieu, R. G. DiScipio, and I. U. Schraufstatter
Arrestin Regulates MAPK Activation and Prevents NADPH Oxidase-dependent Death of Cells Expressing CXCR2
J. Biol. Chem.,
November 19, 2004;
279(47):
49259 - 49267.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J.-D. Luo, Y.-Y. Wang, W.-L. Fu, J. Wu, and A. F. Chen
Gene Therapy of Endothelial Nitric Oxide Synthase and Manganese Superoxide Dismutase Restores Delayed Wound Healing in Type 1 Diabetic Mice
Circulation,
October 19, 2004;
110(16):
2484 - 2493.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. T. Quinn and K. A. Gauss
Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases
J. Leukoc. Biol.,
October 1, 2004;
76(4):
760 - 781.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. M. Browe and C. M. Baumgarten
Angiotensin II (AT1) Receptors and NADPH Oxidase Regulate Cl- Current Elicited by {beta}1 Integrin Stretch in Rabbit Ventricular Myocytes
J. Gen. Physiol.,
August 30, 2004;
124(3):
273 - 287.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. D. Hoppe and J. A. Swanson
Cdc42, Rac1, and Rac2 Display Distinct Patterns of Activation during Phagocytosis
Mol. Biol. Cell,
August 1, 2004;
15(8):
3509 - 3519.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. M. Fuhler, K. A. Cadwallader, G. J. Knol, E. R. Chilvers, A. L. Drayer, and E. Vellenga
Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia
J. Leukoc. Biol.,
July 1, 2004;
76(1):
254 - 262.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. L. Wong, T. Sakamoto, T. Kawasaki, K. Umemura, and K. Shimamoto
Down-Regulation of Metallothionein, a Reactive Oxygen Scavenger, by the Small GTPase OsRac1 in Rice
Plant Physiology,
July 1, 2004;
135(3):
1447 - 1456.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. D. Topp, N. W. Gray, R. D. Gerard, and B. F. Horazdovsky
Alsin Is a Rab5 and Rac1 Guanine Nucleotide Exchange Factor
J. Biol. Chem.,
June 4, 2004;
279(23):
24612 - 24623.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. van Bruggen, E. Anthony, M. Fernandez-Borja, and D. Roos
Continuous Translocation of Rac2 and the NADPH Oxidase Component p67phox during Phagocytosis
J. Biol. Chem.,
March 5, 2004;
279(10):
9097 - 9102.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. L. Petheo, A. Maturana, A. Spat, and N. Demaurex
Interactions between Electron and Proton Currents in Excised Patches from Human Eosinophils
J. Gen. Physiol.,
November 24, 2003;
122(6):
713 - 726.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Noda, M. Kohjima, T. Izaki, K. Ota, S. Yoshinaga, F. Inagaki, T. Ito, and H. Sumimoto
Molecular Recognition in Dimerization between PB1 Domains
J. Biol. Chem.,
October 31, 2003;
278(44):
43516 - 43524.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Maack, T. Kartes, H. Kilter, H.-J. Schafers, G. Nickenig, M. Bohm, and U. Laufs
Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment
Circulation,
September 30, 2003;
108(13):
1567 - 1574.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. R. Sekhar, P. A. Crooks, V. N. Sonar, D. B. Friedman, J. Y. Chan, M. J. Meredith, J. H. Starnes, K. R. Kelton, S. R. Summar, S. Sasi, et al.
NADPH Oxidase Activity Is Essential for Keap1/Nrf2-mediated Induction of GCLC in Response to 2-Indol-3-yl-methylenequinuclidin-3-ols
Cancer Res.,
September 1, 2003;
63(17):
5636 - 5645.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. Falzano, M. G. Quaranta, S. Travaglione, P. Filippini, A. Fabbri, M. Viora, G. Donelli, and C. Fiorentini
Cytotoxic Necrotizing Factor 1 Enhances Reactive Oxygen Species-Dependent Transcription and Secretion of Proinflammatory Cytokines in Human Uroepithelial Cells
Infect. Immun.,
July 1, 2003;
71(7):
4178 - 4181.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Takeya, N. Ueno, K. Kami, M. Taura, M. Kohjima, T. Izaki, H. Nunoi, and H. Sumimoto
Novel Human Homologues of p47phox and p67phox Participate in Activation of Superoxide-producing NADPH Oxidases
J. Biol. Chem.,
June 27, 2003;
278(27):
25234 - 25246.
[Abstract]
[Full Text]
[PDF]
|
 |
|
|
|