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Prepublished online as a Blood First Edition Paper on September 26, 2002; DOI 10.1182/blood-2002-04-1183. This Article Full Text (PDF) All Versions of this Article: 2002-04-1183v1 101/2/415    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Henderson, J. N Articles by DeBaun, M. R Search for Related Content PubMed PubMed Citation Articles by Henderson, J. N Articles by DeBaun, M. R Social Bookmarking                   What's this? Submitted April 19, 2002 Accepted July 24, 2002 Reversible Posterior Leukoencephalopathy Syndrome and silent cerebral infarcts are associated with severe Acute Chest Syndrome in children with Sickle Cell Disease Jessica N Henderson, Michael J Noetzel, Robert C McKinstry, Desiree A White, Melissa Armstrong, and Michael R DeBaun* Pediatrics, Division of Hematology/ Onclolgy, Washington University School of Medicine, St. Louis, MO, USA Neurology, Pediatrics, Washington University School of Medicine, St. Louis, MO, USA Mallinkrodt Institute of Radiology, Neuroradiology, Washington University School of Medicine, St. Louis, MO, USA Department of Psychology, Washington University, St. Louis, MO, USA * Corresponding author; email: debaun_m{at}kids.wustl.edu. Patients with severe Acute Chest Syndrome (ACS) requiring endotracheal intubation and erythrocytapheresis may be at an increased risk of neurologic morbidity. This study examines patients with sickle cell disease who developed severe episodes of ACS leading to endotracheal intubation, ventilatory support for respiratory failure and erythrocytapheresis. Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) studies, a neurologic examination by a pediatric neurologist and cognitive testing were done in all patients. Five consecutive patients, ages 3 to 9 years, were identified with severe ACS. All patients developed neurologic complications resulting from ACS episodes including seizures (n=2), silent cerebral infarcts (n=3), cerebral hemorrhage (n=2), and Reversible Posterior Leukoencephalopathy Syndrome (n=3). Children with severe ACS should have a MRI of the brain, neurologic examination by a neurologist, and cognitive testing to detect the presence of neurologic morbidity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J Pappachan and F J Kirkham Cerebrovascular disease and stroke Arch. Dis. Child., October 1, 2008; 93(10): 890 - 898. [Abstract] [Full Text] [PDF] E. S. Roach, M. R. Golomb, R. Adams, J. Biller, S. Daniels, G. deVeber, D. Ferriero, B. V. Jones, F. J. Kirkham, R. M. Scott, et al. Management of Stroke in Infants and Children: A Scientific Statement From a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young Stroke, September 1, 2008; 39(9): 2644 - 2691. [Abstract] [Full Text] [PDF] J. J. Strouse, M. L. Hulbert, M. R. DeBaun, L. C. Jordan, and J. F. Casella Primary Hemorrhagic Stroke in Children With Sickle Cell Disease Is Associated With Recent Transfusion and Use of Corticosteroids Pediatrics, November 1, 2006; 118(5): 1916 - 1924. [Abstract] [Full Text] [PDF] S. T. Miller, S. P. Rao, J. H. Boyd, and M. R. DeBaun Acute chest syndrome, transfusion, and neurologic events in children with sickle cell disease Blood, August 15, 2003; 102(4): 1556 - 1557. [Full Text] [PDF]

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