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Prepublished online as a Blood First Edition Paper on June 28, 2002; DOI 10.1182/blood-2002-04-1188.
Submitted April 19, 2002
Accepted June 6, 2002
Centrosome aberrations in acute myeloid leukemia are correlated to cytogenetic risk profile
Kai Neben, Christian Giesecke, Silja Schweizer, Anthony D Ho, and Alwin Kraemer*
Medizinische Klinik und Poliklinik V, Universitaet Heidelberg, Heidelberg, Germany
* Corresponding author; email: Alwin_Kraemer{at}med.uni-heidelberg.de.
Genetic instability is a common feature in acute myeloid leukemia (AML). Recently, centrosome aberrations have been described as a possible cause of aneuploidy in many human tumors. To investigate whether centrosome aberrations correlate with cytogenetic findings in AML, we examined a set of 51 AML patients using a centrosome-specific antibody to pericentrin. All 51 AML analyzed displayed numerical and structural centrosome aberrations (36.0 ± 16.6%) as compared to peripheral blood mononuclear cells from 21 healty volunteers (5.2 ± 2.0%; p<0.0001). In comparison to AML patients with normal chromosome count, the extent of numerical and structural centrosome aberrations was higher in patients with numerical chromosome changes (50.5 ± 14.2% vs 34.3 ± 12.2%; p<0.0001). When the frequency of centrosome aberrations was analyzed within cytogenetical defined risk groups, we found a correlation of the extent of centrosome abnormalities to all three risk groups (p=0.0015), defined as favorable (22.5 ± 7.3%), intermediate (35.3 ± 13.1%) and adverse (50.3 ± 15.6%). These results indicate that centrosome defects may contribute to the aquisition of chromosome aberrations and thereby to the prognosis in AML.
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