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Prepublished online as a Blood First Edition Paper on August 22, 2002August 8, 2002; DOI 10.1182/blood-2002-04-1246. This Article Full Text (PDF) All Versions of this Article: 2002-04-1246v1 2002-04-1246v2 100/13/4266    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Quesenberry, P. J Articles by Lambert, J.-F. Search for Related Content PubMed PubMed Citation Articles by Quesenberry, P. J Articles by Lambert, J.-F. Social Bookmarking                   What's this? Submitted April 26, 2002 Accepted July 19, 2002 The Chiaroscuro stem cell: a unified stem cell theory Peter J Quesenberry*, Gerald A Colvin, and Jean-Francois Lambert Department of Research, Roger Williams Medical Center, Providence, RI, USA * Corresponding author; email: pquesenberry{at}rwmc.org. Hematopoiesis has been felt to be hierarchical in nature, but recent data suggests that the system is not hierarchical and, is in fact, quite functionally plastic. Existing data indicate that engraftment and progenitor phenotypes vary inversely with cell cycle transit and that gene expression varies widely also. These observations suggest that there is no progenitor/stem cell hierarchy, but rather a reversible continuum. This may, in turn, be dependent on shifting chromatin and gene expression with cell transit. If the phenotype of these primitive marrow cells change from engraftable stem cell to progenitor and back to engraftable stem cell with cell cycle transit, then this suggests that the identity of the engraftable stem cell may be partially masked in non-synchronized marrow cell populations. A general model indicates a marrow cell that can continually change its surface receptor expression and thus responds to external stimuli differently at different points in cell cycle. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Cesselli, A. P. Beltrami, S. Rigo, N. Bergamin, F. D'Aurizio, R. Verardo, S. Piazza, E. Klaric, R. Fanin, B. Toffoletto, et al. Multipotent Progenitor Cells Are Present in Human Peripheral Blood Circ. Res., May 22, 2009; 104(10): 1225 - 1234. [Abstract] [Full Text] [PDF] T. Magnus, Y. Liu, G. C Parker, and M. 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