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Prepublished online as a Blood First Edition Paper on August 22, 2002; DOI 10.1182/blood-2002-05-1299. This Article Full Text (PDF) All Versions of this Article: 2002-05-1299v1 100/13/4259    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Choi, E. Y. Articles by Roopenian, D. C Search for Related Content PubMed PubMed Citation Articles by Choi, E. Y. Articles by Roopenian, D. C Social Bookmarking                   What's this? Submitted May 2, 2002 Accepted July 22, 2002 Real-time T cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-vs-host disease Eun Young Choi, Gregory J Christianson, Toshitaka Yoshimura, Nadja Jung, Thomas J Sproule, Subramaniam Malarkannan, Sebastian Joyce, and Derry C Roopenian* The Jackson Laboratory, Bar Harbor, ME, USA Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA * Corresponding author; email: dcr{at}jax.org. Although CD8 T cells are thought to be a principal effector population of graft-versus-host (GVHD) disease, their dynamics and specificity remain a mystery. Using a mouse model in which donor and recipient were incompatible at many minor histocompatibility antigens (minor H Ags), the CD8 T cell response was tracked temporally and spatially through the course of GVHD. Donor CD8 T cells in the circulation, spleen, lung and liver demonstrated virtually identical kinetics: rapid expansion and then decline prior to morbidity. Remarkably, up to 1/4 of the CD8 T cells were directed against a single minor antigen, H60. Extreme H60 immunodominance occurred regardless of sampling time, site and genetic background and matching for H60 delayed onset of morbidity. This study is the first to analyze the T cells participating in GVHD in "real-time", demonstrates the exceptional degree to which immunodominance of H60 can occur, and suggests that such superdominant minor H Ags could be risk factors for GVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Zheng, C. Matte-Martone, D. Jain, J. McNiff, and W. D. Shlomchik Central Memory CD8+ T Cells Induce Graft-versus-Host Disease and Mediate Graft-versus-Leukemia J. Immunol., May 15, 2009; 182(10): 5938 - 5948. 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