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Prepublished online as a Blood First Edition Paper on October 24, 2002; DOI 10.1182/blood-2002-05-1336. This Article Full Text (PDF) All Versions of this Article: 2002-05-1336v1 101/6/2219    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dumortier, A. Articles by Chan, S. Search for Related Content PubMed PubMed Citation Articles by Dumortier, A. Articles by Chan, S. Social Bookmarking                   What's this? Submitted May 6, 2002 Accepted October 21, 2002 Ikaros regulates neutrophil differentiation Alexis Dumortier, Peggy Kirstetter, Philippe Kastner*, and Susan Chan Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France * Corresponding author; email: scpk{at}igbmc.u-strasbg.fr. The Ikaros gene encodes a zinc finger transcription factor that is selectively expressed by all hematopoietic cells. Although Ikaros is required for lymphocyte differentiation, its role in the myeloid lineage is unclear. We show here that Ikaros expression is temporally regulated during neutrophil differentiation: Ikaros is primarily expressed at immature stages and significantly less so in mature neutrophils. Furthermore IkL/L mice, harboring a hypomorphic mutation at the Ikaros locus, exhibit several defects during neutrophil differentiation. (i) IkL/L fetal livers contain high numbers of neutrophil lineage cells, and this increase is reflected in the number of GM-CSF-dependent progenitor cells. (ii) The migratory potential and survival of neutrophil progenitors is altered in vitro. (iii) Expression of the Gr-1 marker is delayed and repressed. In contrast, neutrophil function appears normal. These data demonstrate that Ikaros regulates early neutrophil differentiation but is dispensable in mature neutrophils. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Z. Gurel, T. Ronni, S. Ho, J. Kuchar, K. J. Payne, C. W. Turk, and S. Dovat Recruitment of Ikaros to Pericentromeric Heterochromatin Is Regulated by Phosphorylation J. Biol. Chem., March 28, 2008; 283(13): 8291 - 8300. [Abstract] [Full Text] [PDF] T. Ronni, K. J. Payne, S. Ho, M. N. Bradley, G. Dorsam, and S. Dovat Human Ikaros Function in Activated T Cells Is Regulated by Coordinated Expression of Its Largest Isoforms J. Biol. Chem., January 26, 2007; 282(4): 2538 - 2547. [Abstract] [Full Text] [PDF] D. Allman, M. Dalod, C. Asselin-Paturel, T. Delale, S. H. Robbins, G. Trinchieri, C. A. Biron, P. Kastner, and S. Chan Ikaros is required for plasmacytoid dendritic cell differentiation Blood, December 15, 2006; 108(13): 4025 - 4034. [Abstract] [Full Text] [PDF] G. G. Welstead, C. Iorio, R. Draker, J. Bayani, J. Squire, S. Vongpunsawad, R. Cattaneo, and C. D. Richardson Measles virus replication in lymphatic cells and organs of CD150 (SLAM) transgenic mice PNAS, November 8, 2005; 102(45): 16415 - 16420. [Abstract] [Full Text] [PDF] I. Harfi, S. D'Hondt, F. Corazza, and E. Sariban Regulation of Human Polymorphonuclear Leukocytes Functions by the Neuropeptide Pituitary Adenylate Cyclase-Activating Polypeptide after Activation of MAPKs J. Immunol., September 15, 2004; 173(6): 4154 - 4163. [Abstract] [Full Text] [PDF] J. Bystrom, T. A. Wynn, J. B. Domachowske, and H. F. Rosenberg Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow Blood, February 1, 2004; 103(3): 868 - 877. [Abstract] [Full Text] [PDF]

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