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Prepublished online as a Blood First Edition Paper on September 4, 2003; DOI 10.1182/blood-2002-05-1352. This Article Full Text (PDF) All Versions of this Article: 2002-05-1352v1 103/1/236    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tsuchiya, T. Articles by Kikuchi, M. Search for Related Content PubMed PubMed Citation Articles by Tsuchiya, T. Articles by Kikuchi, M. Social Bookmarking                   What's this? Submitted May 8, 2002 Accepted August 24, 2003 Th1, Th2 and activated T-cell marker, and clinical prognosis in peripheral T-cell lymphoma, unspecified: comparison with AILD, ALCL, lymphoblastic lymphoma, and ATLL Takeshi Tsuchiya, Koichi Ohshima*, Kennosuke Karube, Takahiro Yamaguchi, Hiroaki Suefuji, Makoto Hamasaki, Chika Kawasaki, Junji Suzumiya, Masao Tomonaga, and Masahiro Kikuchi Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan * Corresponding author; email: ohshima{at}fukuoka-u.ac.jp. A new WHO classification was recently proposed. However, classification of peripheral T-cell lymphomas remains to be clarified. Particularly, unspecified type was considered as a heterogeneous category. Here we studied the expressions of chemokine receptors, Th1 associated CXCR3 and CCR5 and Th2 associated marker ST2(L), and activated T-cell receptor OX40/CD134 in 185 cases with nodal T-cell lymphoma, and evaluated the relation to prognosis. The expression pattern of them correlated with the specific subtype of nodal T-cell lymphoma, such as AILD (angioimmunoblastic T-cell lymphoma), ALCL (anaplastic large cell lymphoma) and in PTCL (peripheral T-cell lymphoma), unspecified. In AILD, almost all cases were immunoreactive for OX40/CD134 (96%) and for CXCR3 (89%). In ALCL, all cases were immunonegative for OX40/CD134 and only a few cases (24%) were immunoreactive for CXCR3, while almost all cases (94%) were positive for ST2(L). Cases of PTCL, unspecified were divided into two groups; Group I (cases positive for either ST2(L), CCR5 or CXCR3) tended to show favorable prognosis, compared with Group II (cases negative for ST2(L), CCR5 and CXCR3). Our results indicate that further subtyping of PTCL, unspecified, into groups I and II could be significant for evaluation of prognosis and understanding the functional role of these tumors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Nakagawa, A. Nakagawa-Oshiro, S. Karnan, H. Tagawa, A. Utsunomiya, S. Nakamura, I. Takeuchi, K. Ohshima, and M. Seto Array Comparative Genomic Hybridization Analysis of PTCL-U Reveals a Distinct Subgroup with Genetic Alterations Similar to Lymphoma-Type Adult T-Cell Leukemia/Lymphoma Clin. Cancer Res., January 1, 2009; 15(1): 30 - 38. [Abstract] [Full Text] [PDF] S. Mercadal, J. Briones, B. Xicoy, C. Pedro, L. Escoda, C. Estany, M. Camos, L. Colomo, I. Espinosa, S. Martinez, et al. Intensive chemotherapy (high-dose CHOP/ESHAP regimen) followed by autologous stem-cell transplantation in previously untreated patients with peripheral T-cell lymphoma Ann. 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