SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on September 12, 2002; DOI 10.1182/blood-2002-05-1392. This Article Full Text (PDF) All Versions of this Article: 2002-05-1392v1 101/3/846    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hargrave, D. R Articles by Kirkham, F. J Search for Related Content PubMed PubMed Citation Articles by Hargrave, D. R Articles by Kirkham, F. J Social Bookmarking                   What's this? Submitted May 30, 2002 Accepted August 26, 2002 Nocturnal oxygen saturation and painful sickle cell crises in children Darren R Hargrave*, Angie Wade, Jane P M Evans, Deborah K M Hewes, and Fenella J Kirkham Paediatric Oncology Unit, Royal Marsden Hospital, Sutton, United Kingdom Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom Department of Haematology, University College Hospital, London, United Kingdom Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom * Corresponding author; email: d.hargrave{at}icr.ac.uk. The pathogenesis of acute painful crisis in children with sickle cell disease is poorly understood; suggested risk factors include sickle cell type, severity of anemia, fetal hemoglobin concentration and hypoxemia from upper airways obstruction. In a cohort study of 95 patients the relationship between clinical, laboratory and sleep study data and frequency of painful crisis was investigated. Both univariate and multiple regression modelling showed that low nocturnal oxygen saturation was highly significantly associated with a higher rate of painful crisis in childhood (p<0.0001). Screening and treatment for hypoxemia may reduce the frequency of this and other complications of the disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: I M Balfour-Lynn, D J Field, P Gringras, B Hicks, E Jardine, R C Jones, A G Magee, R A Primhak, M P Samuels, N J Shaw, et al. BTS guidelines for home oxygen in children Thorax, August 1, 2009; 64(Suppl_2): ii1 - ii26. [Full Text] [PDF] M. J. Marshall, R. S. Bucks, A. M. Hogan, I. R. Hambleton, S. E. Height, M. C. Dick, F. J. Kirkham, and D. C. Rees Auto-adjusting positive airway pressure in children with sickle cell anemia: results of a phase I randomized controlled trial Haematologica, July 1, 2009; 94(7): 1006 - 1010. [Abstract] [Full Text] [PDF] C. P. Minniti, C. Sable, A. Campbell, S. Rana, G. Ensing, N. Dham, O. Onyekwere, M. Nouraie, G. J. Kato, M. T. Gladwin, et al. Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation Haematologica, March 1, 2009; 94(3): 340 - 347. [Abstract] [Full Text] [PDF] F. D. Pashankar, J. Carbonella, A. Bazzy-Asaad, and A. Friedman Prevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease Pediatrics, April 1, 2008; 121(4): 777 - 782. [Abstract] [Full Text] [PDF] K. R. Casey, K. O. Cantillo, and L. K. Brown Sleep-Related Hypoventilation/Hypoxemic Syndromes Chest, June 1, 2007; 131(6): 1936 - 1948. [Abstract] [Full Text] [PDF] J. H. Boyd, E. A. Macklin, R. C. Strunk, and M. R. DeBaun Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia Blood, November 1, 2006; 108(9): 2923 - 2927. [Abstract] [Full Text] [PDF] A K Siddiqui and S Ahmed Pulmonary manifestations of sickle cell disease Postgrad. Med. J., July 1, 2003; 79(933): 384 - 390. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020