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 Prepublished online as a Blood First Edition Paper on October 17, 2002; DOI 10.1182/blood-2002-05-1426.

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Submitted May 15, 2002
Accepted October 2, 2002

All-trans retinoic acid induces CD52 expression in acute promyelocytic leukemia

Shi-Wu Li, Dongqi Tang, Kim P Ahrens, Jin-Xiong She, Raul C Braylan, and Lijun Yang*

Pathology, University of Florida, Gainesville, Florida, USA

* Corresponding author; email: yanglj{at}pathology.ufl.edu.

It is well known that All-trans-retinoic acid (ATRA) can induce myeloid cell differentiation in acute promyelocytic leukemic (APL) cells. In this study, we found that ATRA treatment of the APL cell line NB4 induced the expression of CD52, both at transcriptional and translational levels. CD52 is a 21 to 28-kDa-nonmodulating cell surface glycosyl-phosphatidyl-inositol-linked glycoprotein expressed on lymphocytes, monocytes, but not in human myeloid cells. The ATRA-dependent induction of CD52 expression was not observed in non-promyelocytic leukemia cell lines such as K562, U937 and HL-60, suggesting that induction of CD52 by ATRA may be specific to leukemic cells that express PML-RAR{alpha} or are at the promyelocytic stage of myeloid development. Antibodies against CD52 are used therapeutically against lymphocytes in certain leukemias and in transplantation patients. ATRA-induced high level of CD52 expression might potentially serve as a novel therapeutic target in treatment of acute promyelocytic leukemia.


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