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Prepublished online as a Blood First Edition Paper on September 26, 2002; DOI 10.1182/blood-2002-05-1432. This Article Full Text (PDF) All Versions of this Article: 2002-05-1432v1 101/4/1484    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Borges, L. Articles by Kuhlman, T. Search for Related Content PubMed PubMed Citation Articles by Borges, L. Articles by Kuhlman, T. Social Bookmarking                   What's this? Submitted May 16, 2002 Accepted September 17, 2002 LIR9, an Ig-superfamily activating receptor, is expressed as a transmembrane and a secreted molecule Luis Borges*, Marek Kubin, and Tracy Kuhlman Department of Cancer Biology, Amgen Inc, Seattle, WA, USA Department of Inflammation, Amgen Inc, Seattle, WA, USA * Corresponding author; email: borgesl{at}amgen.com. LIRs are immunoglobulin-like receptors that have both activating and inhibitory functions in leukocytes. Here we report the identification of the first LIR family member, LIR9, that is expressed both as a membrane-bound receptor and a secreted molecule. We identified 4 different forms of LIR9, two of which encode transmembrane molecules and two that encode secreted molecules. The transmembrane forms of LIR9 contain a short cytoplasmic domain and a charged arginine residue within the transmembrane region, which is likely to mediate its association with another co-receptor. LIR9 is mostly expressed in myeloid cells including monocytes and neutrophils. Crosslinking of LIR9 on the surface of monocytes induces calcium flux and secretion of the pro-inflammatory cytokines IL-1ß, TNF-, and IL-6, indicating that LIR9 could play a role in triggering innate immune responses. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. Tedla, C.-W. Lee, L. Borges, C. L. Geczy, and J. P. Arm Differential expression of leukocyte immunoglobulin-like receptors on cord blood-derived human mast cell progenitors and mature mast cells J. Leukoc. Biol., February 1, 2008; 83(2): 334 - 343. [Abstract] [Full Text] [PDF] R. J. Lebbink, M. C. W. van den Berg, T. de Ruiter, N. Raynal, J. A. G. van Roon, P. J. Lenting, B. Jin, and L. Meyaard The Soluble Leukocyte-Associated Ig-Like Receptor (LAIR)-2 Antagonizes the Collagen/LAIR-1 Inhibitory Immune Interaction J. Immunol., February 1, 2008; 180(3): 1662 - 1669. [Abstract] [Full Text] [PDF] S. Hahtola, S. Tuomela, L. Elo, T. Hakkinen, L. Karenko, B. Nedoszytko, H. Heikkila, U. Saarialho-Kere, J. Roszkiewicz, T. Aittokallio, et al. Th1 Response and Cytotoxicity Genes Are Down-Regulated in Cutaneous T-Cell Lymphoma. Clin. Cancer Res., August 15, 2006; 12(16): 4812 - 4821. [Abstract] [Full Text] [PDF] M. Shiroishi, M. Kajikawa, K. Kuroki, T. Ose, D. Kohda, and K. Maenaka Crystal Structure of the Human Monocyte-activating Receptor, "Group 2" Leukocyte Ig-like Receptor A5 (LILRA5/LIR9/ILT11) J. Biol. Chem., July 14, 2006; 281(28): 19536 - 19544. [Abstract] [Full Text] [PDF]

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