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Prepublished online as a Blood First Edition Paper on October 3, 2002; DOI 10.1182/blood-2002-05-1576. This Article Full Text (PDF) All Versions of this Article: 2002-05-1576v1 101/3/815    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Smith, J. R Articles by Rosenbaum, J. T Search for Related Content PubMed PubMed Citation Articles by Smith, J. R Articles by Rosenbaum, J. T Social Bookmarking                   What's this? Submitted May 28, 2002 Accepted September 10, 2002 Expression of B cell-attracting chemokine-1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma Justine R Smith*, Rita M Braziel, Samantha Paoletti, Martin Lipp, Mariagrazia Uguccioni, and James T Rosenbaum Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA Department of Pathology, Oregon Health & Science University, Portland, OR, USA Institute for Research in Biomedicine, Bellinzona, Switzerland Max-Delbrueck-Center for Molecular Medicine, Berlin-Buch, Germany * Corresponding author; email: smithjus{at}ohsu.edu. Primary central nervous system lymphoma (PCNSL) is a rare, but often rapidly fatal form of non-Hodgkin B cell lymphoma that arises within the CNS and has a low propensity to metastasize. We performed immunohistochemistry on formalin-fixed, paraffin-embedded brain biopsy specimens from 24 patients with PCNSL, to investigate the expression of B cell-attracting chemokine-1 (BCA-1, CXCL13), a lymphoid chemokine involved in B cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. While BCA-1 was not detected in normal human brain, all 24 brain biopsy specimens containing PCNSL were positive for BCA-1. Double-immunostaining on selected specimens localized BCA-1 to malignant B lymphocytes and vascular endothelium. In contrast, two chemokines implicated particularly in T cell movement, secondary lymphoid tissue chemokine (SLC, CCL21) and Epstein-Barr virus-induced molecule 1 ligand chemokine (ELC, CCL19), were expressed only by occasional stromal cells in 2 and 4 of the 24 specimens, respectively. Tumor cells stained positively for CXCR5, the primary receptor for BCA-1. In situ hybridization verified the expression of BCA-1 mRNA by malignant B cells, but not vascular endothelium, within the tumor mass, suggesting that vascular endothelial BCA-1 expression may be consequent to transcytosis. In PCNSL, expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and/or localization to CNS. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Fischer, A. Korfel, S. Pfeiffer, P. Kiewe, H.-D. Volk, H. Cakiroglu, T. Widmann, and E. Thiel CXCL13 and CXCL12 in Central Nervous System Lymphoma Patients Clin. Cancer Res., October 1, 2009; 15(19): 5968 - 5973. [Abstract] [Full Text] [PDF] L.-Y. Feng, Z.-L. Ou, F.-Y. Wu, Z.-Z. Shen, and Z.-M. Shao Involvement of a Novel Chemokine Decoy Receptor CCX-CKR in Breast Cancer Growth, Metastasis and Patient Survival Clin. Cancer Res., May 1, 2009; 15(9): 2962 - 2970. [Abstract] [Full Text] [PDF] M. 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