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Prepublished online as a Blood First Edition Paper on October 24, 2002; DOI 10.1182/blood-2002-05-1581. This Article Full Text (PDF) All Versions of this Article: 2002-05-1581v1 101/5/1871    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ameri, A. Articles by Kurachi, K. Search for Related Content PubMed PubMed Citation Articles by Ameri, A. Articles by Kurachi, K. Social Bookmarking                   What's this? Submitted May 30, 2002 Accepted October 9, 2002 Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX Afshin Ameri, Sumiko Kurachi, Katsuo Sueishi, Mitsuhiro Kuwahara, and Kotoku Kurachi* Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA Department of Pathology, Kyushu University, Fukuoka, Fukuoka, Japan Gene Discovery Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaragi, Japan * Corresponding author; email: kkurachi{at}umich.edu. Elevated circulatory levels of many blood coagulation factors are known to be a risk factor for deep vein thrombosis in humans. Here we report the first direct demonstration of a close association between elevated circulatory factor IX levels in mice with thrombosis as well as myocardial fibrosis. Transgenic mice over-expressing human factor IX at persistently high levels died at much younger ages than their cohorts expressing lower levels or non-transgenic control animals. The median survival age of animals was inversely related to the circulatory levels of human factor IX. Prematurely dying animals had focal fibrotic lesions predominantly present in the left ventricular myocardium, and vasculatures in these lesions showed fibrin deposition. Thromboemboli were also present in other organs, including lung and brain. These observations support that persistently high circulatory levels of factor IX are a risk factor not only for thrombosis and/or thromboembolism, but also for myocardial fibrosis mimicking human myocardial infarction. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Yoshizawa, G. E. Kissling, J. A. Johnson, N. P. Clayton, N. D. Flagler, and A. Nyska Chemical-Induced Atrial Thrombosis in NTP Rodent Studies Toxicol Pathol, August 1, 2005; 33(5): 517 - 532. [Abstract] [Full Text] [PDF]

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