SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on September 12, 2002; DOI 10.1182/blood-2002-05-1592. This Article Full Text (PDF) All Versions of this Article: 2002-05-1592v1 101/2/706    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wlodarska, I. Articles by Hagemeijer, A. Search for Related Content PubMed PubMed Citation Articles by Wlodarska, I. Articles by Hagemeijer, A. Social Bookmarking                   What's this? Submitted May 29, 2002 Accepted August 21, 2002 Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin's lymphoma but not in classical Hodgkin's lymphoma Iwona Wlodarska, Peet Nooyen, Brigitte Maes, Jose I Martin-Subero, Reiner Siebert, Patrick Pauwels, Chris De Wolf-Peeters, and Anne Hagemeijer* Center for Human Genetics, Catholic University of Leuven, Leuven, Belgium Department of Pathology, Stichting PAMM, Eindhoven, The Netherlands Division for Morphology and Molecular Pathology, Catholic University of Leuven, Leuven, Belgium Institute of Human Genetics, University Hospital Kiel, Kiel, Germany * Corresponding author; email: anne.hagemeijer{at}med.kuleuven.ac.be. We studied the genomic status of BCL6 in 23 cases of nodular lymphocyte predominance Hodgkin's lymphoma (NLPHL) and 40 cases of classical Hodgkin's lymphoma (cHL) using dual color interphase-FISH. The BCL6 rearrangement was identified in 48% of NLPHL cases and not detected in cHL cases. As a confirmation, sequential or simultaneous IHC/FISH using CD20 or BCL6 antibodies and BCL6 DNA probes was performed in 8 NLPHL cases. The BCL6-associated translocations, t(3;22)(q27;q11), t(3;7)(q27;p12), and the most probable t(3;9)(q27;p13) were identified in 3 cases. A consistent expression of BCL6 protein in popcorn cells with the highest number of intensely stained cells in cases with a genomic BCL6 rearrangement was shown by immunohistochemistry. In summary, presented findings support the hypothesis of germinal center B cell derived-origin of NLPHL, indicate a significant role of BCL6 in pathogenesis of NLPHL, and provide further evidence of the genetic diversity underlying pathogenesis of NLPHL and cHL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: V. Brune, E. Tiacci, I. Pfeil, C. Doring, S. Eckerle, C. J.M. van Noesel, W. Klapper, B. Falini, A. von Heydebreck, D. Metzler, et al. Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis J. Exp. Med., September 29, 2008; 205(10): 2251 - 2268. [Abstract] [Full Text] [PDF] J. I. Martin-Subero, W. Klapper, A. Sotnikova, E. Callet-Bauchu, L. Harder, C. Bastard, R. Schmitz, S. Grohmann, J. Hoppner, J. Riemke, et al. Chromosomal Breakpoints Affecting Immunoglobulin Loci Are Recurrent in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin Lymphoma Cancer Res., November 1, 2006; 66(21): 10332 - 10338. [Abstract] [Full Text] [PDF] Y.-W. Chen, X.-T. Hu, A. C. Liang, W.-Y. Au, C.-C. So, M. L. Wong, L. Shen, Q. Tao, K.-M. Chu, Y.-L. Kwong, et al. High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma Blood, October 1, 2006; 108(7): 2373 - 2383. [Abstract] [Full Text] [PDF] A. Liso, D. Capello, T. Marafioti, E. Tiacci, M. Cerri, V. Distler, M. Paulli, A. Carbone, G. Delsol, E. Campo, et al. Aberrant somatic hypermutation in tumor cells of nodular-lymphocyte-predominant and classic Hodgkin lymphoma Blood, August 1, 2006; 108(3): 1013 - 1020. [Abstract] [Full Text] [PDF] D. Re, R. Kuppers, and V. Diehl Molecular Pathogenesis of Hodgkin's Lymphoma J. Clin. Oncol., September 10, 2005; 23(26): 6379 - 6386. [Abstract] [Full Text] [PDF] C. Renne, J. I. Martin-Subero, M.-L. Hansmann, and R. Siebert Molecular Cytogenetic Analyses of Immunoglobulin Loci in Nodular Lymphocyte Predominant Hodgkin's Lymphoma Reveal a Recurrent IGH-BCL6 Juxtaposition J. Mol. Diagn., August 1, 2005; 7(3): 352 - 356. [Abstract] [Full Text] [PDF] S. Poppema Immunobiology and Pathophysiology of Hodgkin Lymphomas Hematology, January 1, 2005; 2005(1): 231 - 238. [Abstract] [Full Text] [PDF] T. Katzenberger, G. Ott, T. Klein, J. Kalla, H. K. Muller-Hermelink, and M. M. Ott Cytogenetic Alterations Affecting BCL6 Are Predominantly Found in Follicular Lymphomas Grade 3B with a Diffuse Large B-Cell Component Am. J. Pathol., August 1, 2004; 165(2): 481 - 490. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020