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Prepublished online as a Blood First Edition Paper on January 9, 2003; DOI 10.1182/blood-2002-05-1597. This Article Full Text (PDF) All Versions of this Article: 2002-05-1597v1 101/9/3407    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Toro, J. R Articles by Jaffe, E. S Search for Related Content PubMed PubMed Citation Articles by Toro, J. R Articles by Jaffe, E. S Social Bookmarking                   What's this? Submitted May 31, 2002 Accepted December 31, 1969 Gamma delta () T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma Jorge R Toro*, David J Liewehr, Nina Pabby, Lynn Sorbara, Mark Raffeld, Seth M Steinberg, and Elaine S Jaffe National Cancer Institute, National Institutes of Health, Rockville, MD, USA * Corresponding author; email: torojo{at}exchange.nih.gov. BACKGROUND: The importance of vs. T-cell subset antigen expression in the classification of peripheral T-cell lymphomas is still unclear. The objective of this study was to investigate the prognostic value of TCRd1 expression in cutaneous T-cell lymphoma as related to other clinical and pathological features. METHODS: TCR1 cellular expression was assessed in skin biopsy specimens of 104 individuals with cutaneous T-cell lymphoma by immunohistochemistry. Both univariate (Kaplan-Meier) and multivariate (Cox regression) analyses were conducted to determine which variables (T-cell subtype, hemophagocytosis, histologic profile, age, sex, and adenopathy) were significantly associated with survival. RESULTS: Univariate analysis indicated that there was a statistically significant difference in survival between the patients with cutaneous T-cell lymphoma and patients with cutaneous T-cell lymphoma (p<0.0001). There was also a statistically significant decrease in survival among patients who had subcutaneous involvement compared with patients who had epidermotropic and/or dermal involvement (p<0.0001). A Cox model analysis was also done to evaluate factors simultaneously, and prognostic factors considered in the Cox analysis included: T-cell type, histologic profile, and sex. This analysis indicated that TCR1 expression was the factor that was most closely associated with decreased survival (P<0.0001). Among those patients with cutaneous T-cell lymphoma (n=33), there was a trend for decreased survival for patients who had histological evidence of subcutaneous fat involvement in comparison to patients who had epidermotropic or dermal patters of infiltration (P=0.067). No other prognostic factors were identified as having a notable association with outcome in this subgroup. CONCLUSION: TCR1 expression in cutaneous lymphomas is an independent prognostic factor associated with decreased survival. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Roullet, S. M.F. Gheith, J. Mauger, J. M. Junkins-Hopkins, and J. K. Choi Percentage of {gamma}{delta} T Cells in Panniculitis by Paraffin Immunohistochemical Analysis Am J Clin Pathol, June 1, 2009; 131(6): 820 - 826. [Abstract] [Full Text] [PDF] B. Poligone, L. D. Wilson, A. Subtil, and P. 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