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Prepublished online as a Blood First Edition Paper on October 10, 2002; DOI 10.1182/blood-2002-06-1644. This Article Full Text (PDF) All Versions of this Article: 2002-06-1644v1 101/4/1213    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sopper, S. Articles by Mueller, J. G Search for Related Content PubMed PubMed Citation Articles by Sopper, S. Articles by Mueller, J. G Social Bookmarking                   What's this? Submitted June 5, 2002 Accepted September 24, 2002 Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers and T-cell turnover in different organs of rhesus monkeys Sieghart Sopper*, Dagmar Nierwetberg, Astrid Halbach, Ursula Sauer, Carsten Scheller, Christiane Stahl-Hennig, Kerstin Maetz-Rensing, Frank Schaefer, Thomas Schneider, Volker ter Meulen, and Justus G Mueller Institut fuer Virologie und Immunobiologie, Universitaet Wuerzburg, Wuerzburg, Germany Institut fuer Virologie, Deutsches Primatenzentrum, Goettingen, Germany Innere Medizin II, Universitaet des Saarlandes, Homburg/Saar, Germany Institut fuer Pathologie, Universitaet Wuerzburg, Wuerzburg, Germany * Corresponding author; email: sopper{at}vim.uni-wuerzburg.de. HIV-infection leads to reduced numbers and increased turnover of CD4+ T-cells in blood. However, blood represents only two percent of the total lymphocyte pool and information about other organs is lacking, leading to controversy about the effects of HIV-infection on T-cell homeostasis. Therefore, we have determined phenotype and turnover of lymphocyte subsets in various tissues of macaques. Infection with SIV resulted in increased proliferation rates of T-cells in all organs. Despite reduced CD4-counts in blood, absolute numbers of CD4+ T-cells were increased in spleen and lymph nodes and remained stable in nonlymphoid organs such as liver, lung, bone marrow and brain during the asymptomatic phase, indicative for an altered tissue distribution. In animals sacrificed with first signs of AIDS, total body CD4 counts and proliferation rates had returned to control levels whereas thymocytes were almost completely absent. Our data show that a drastically increased turnover in the early stages of HIV-infection, driven by a generalized immune activation rather than a homeostatic response to CD4+ T-cell destruction, is followed by exhaustion of the regenerative capacity of the immune system. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Di Mascio, C. H. Paik, J. A. Carrasquillo, J.-S. Maeng, B.-S. Jang, I. S. Shin, S. Srinivasula, R. Byrum, A. Neria, W. Kopp, et al. Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)-infected nonhuman primates Blood, July 9, 2009; 114(2): 328 - 337. [Abstract] [Full Text] [PDF] V. Monceaux, L. Viollet, F. Petit, M. C. Cumont, G. R. Kaufmann, A. M. Aubertin, B. Hurtrel, G. Silvestri, and J. Estaquier CD4+ CCR5+ T-Cell Dynamics during Simian Immunodeficiency Virus Infection of Chinese Rhesus Macaques J. Virol., December 15, 2007; 81(24): 13865 - 13875. 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