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Prepublished online as a Blood First Edition Paper on August 29, 2002; DOI 10.1182/blood-2002-06-1726.
Submitted June 11, 2002
Accepted August 8, 2002
Genetic analysis of de novo CD5 positive diffuse large B-cell lymphomas suggests an origin from a somatically mutated CD5+ progenitor B cell
Tiemo Katzenberger*, Andreas Lohr, Stephan Schwarz, Martin Dreyling, Julia Schoof, Christina Nickenig, Stephan Stilgenbauer, Joerg Kalla, M Michaela Ott, Hans-Konrad Mueller-Hermelink, and German Ott
Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany
Department of Medicine III; Clinical Cooperative Group, University Hospital Grosshadern/LMU Muenchen, Muenchen, Germany
Department of Internal Medicine III, University of Ulm, Ulm, Germany
* Corresponding author; email: path054{at}mail.uni-wuerzburg.de.
CD5-positive diffuse large B cell lymphomas (DLBL) have recently been described as a particular subgroup of DLBL. Classical banding and interphase cytogenetic analyses targeting ATM, TP53 and P16INK4a genes and the D13S25 locus from thirteen CD5+DLBL were compared to 55 CD5-DLBL. Additionally, analysis of somatic mutations of the IgVH-genes were performed in CD5+DLBL. CD5+DLBL were somatically mutated (7/8 cases) and were negative for the t(11;14)(q13;q32) and the t(14;18)(q32;q21), whereas the t(3;14)(q27;q32) was found in only one tumor. Trisomy 3 and gains on chromosomes 16/16p and 18/18q were significantly over represented in CD5+DLBL. No ATM deletions were detected. The prevalence of deletions at the D13S25 locus was significantly higher in CD5+DLBL (4/12; 33%) in comparison with CD5-DLBL (4/42; 10%), as were p16INK4a deletions (33% vs. 8%). Based on these findings, CD5+DLBL are likely to arise from the same progenitor cell as the mutated variant of CD5+ lymphocytic lymphoma / B-CLL.
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