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Prepublished online as a Blood First Edition Paper on September 19, 2002; DOI 10.1182/blood-2002-06-1793. This Article Full Text (PDF) All Versions of this Article: 2002-06-1793v1 101/2/391    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cheson, B. D Search for Related Content PubMed PubMed Citation Articles by Cheson, B. D Social Bookmarking                   What's this? Submitted June 17, 2002 Accepted August 14, 2002 Radioimmunotherapy of non-Hodgkin's lymphomas Bruce D Cheson* Department of Hematology/Oncology, Georgetown University Hospital, Lombardi Cancer Center, Washington, DC, USA * Corresponding author; email: bdc4{at}georgetown.edu. Enthusiasm for the use of monoclonal antibodies, such as rituximab, has markedly changed the approach to patients with non-Hodgkin lymphomas (NHL). Nevertheless, more effective therapies are needed. Radioimmunotherapy as a form of targeted radiotherapy may add significantly to our therapeutic options. Zevalin (yttrium-90 ibritumomab tiuxetan), recently approved by the Food and Drug Administration, and Bexxar (iodine-131 tositumomab) have demonstrated a high level of activity in patients whose NHL has failed chemotherapy and rituximab. Toxicities have primarily included prolonged myelosuppression, with a potential risk of treatment-associated myelodysplastic syndrome and acute myelogenous leukemia. 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