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Prepublished online as a Blood First Edition Paper on July 17, 2003; DOI 10.1182/blood-2002-06-1813. This Article Full Text (PDF) All Versions of this Article: 2002-06-1813v1 102/10/3822    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Freudenberger, T. D Articles by Hackman, R. C Search for Related Content PubMed PubMed Citation Articles by Freudenberger, T. D Articles by Hackman, R. C Social Bookmarking                   What's this? Submitted June 19, 2002 Accepted July 9, 2003 Association between acute and chronic graft-versus-host disease and bronchiolitis obliterans organizing pneumonia in recipients of hematopoietic stem cell transplants Todd D Freudenberger, David K Madtes, J Randall Curtis, Peter Cummings, Barry E Storer, and Robert C Hackman* Departments of Medicine, Pathology and Laboratory Medicine, University of Washington School of Medicine, Seattle, WA, USA; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA * Corresponding author; email: rhackman{at}seattlecca.org. Bronchiolitis obliterans organizing pneumonia (BOOP) has been reported following hematopoietic stem cell (HSC) transplantation, but the clinical features and risk factors for this disorder have not been well characterized. This case-control study of 49 patients with histological BOOP and 161 control subjects matched by age and year of transplant describes the clinical features and analyzes the risk factors for BOOP following HSC transplantation. Data on clinical features and outcome were collected by chart review. Odds ratios, estimating the relative risk of BOOP in allogeneic HSC recipients, were calculated by conditional logistic regression with adjustment for potential confounding factors. Clinical features of BOOP in this population are similar to idiopathic BOOP and BOOP occurring in other disease settings. There was an association between acute and chronic graft-versus-host disease (GVHD) and the subsequent development of BOOP (odds ratios 3.8 [95% CI, 1.2 to 12.3] and 3.1 [95% CI, 1.1 to 9.2], respectively). Patients with BOOP were more likely to have acute GVHD involving the skin (odds ratio 4.6, P=0.005) and chronic GVHD involving the gut (odds ratio 6.6, P=0.018) and oral cavity (odds ratio 5.9, P=0.026). This study shows that histological BOOP following HSC transplantation has clinical features that resemble idiopathic BOOP and is strongly associated with prior acute and chronic GVHD. These results have important implications for the care of patients who develop respiratory symptoms after HSC transplantation and may help elucidate the pathogenesis of idiopathic BOOP. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. P. Lynch III Rare Interstitial Lung Diseases: Pulmonary Langerhans Cell Histiocytosis, Lymphangioleiomyomatosis, and Cryptogenic Organizing Pneumonia ACCP Pulmonary Med Brd Rev, January 1, 2009; 25(0): 585 - 618. [Full Text] [PDF] D. Siniscalco, N. Sullo, S. Maione, F. Rossi, and B. D'Agostino Review: Stem cell therapy: the great promise in lung disease Therapeutic Advances in Respiratory Disease, June 1, 2008; 2(3): 173 - 177. [Abstract] [PDF] A. Tichelli, A. Rovo, and A. Gratwohl Late Pulmonary, Cardiovascular, and Renal Complications after Hematopoietic Stem Cell Transplantation and Recommended Screening Practices Hematology, January 1, 2008; 2008(1): 125 - 133. [Abstract] [Full Text] [PDF] A. O. Soubani and J. P. Uberti Bronchiolitis obliterans following haematopoietic stem cell transplantation Eur. Respir. J., May 1, 2007; 29(5): 1007 - 1019. [Abstract] [Full Text] [PDF] M. Ditschkowski, A. H. Elmaagacli, R. Trenschel, R. Peceny, M. Koldehoff, C. Schulte, and D. W. Beelen T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donors Haematologica, April 1, 2007; 92(4): 558 - 561. [Abstract] [Full Text] [PDF] J-F. Cordier Cryptogenic organising pneumonia. Eur. Respir. J., August 1, 2006; 28(2): 422 - 446. [Abstract] [Full Text] [PDF] D. L. Coy, A. Ormazabal, J. D. Godwin, and T. Lalani Imaging Evaluation of Pulmonary and Abdominal Complications Following Hematopoietic Stem Cell Transplantation RadioGraphics, March 1, 2005; 25(2): 305 - 317. [Abstract] [Full Text] [PDF] T. Franquet, N. L. Muller, K. S. Lee, A. Gimenez, and J. D. Flint High-Resolution CT and Pathologic Findings of Noninfectious Pulmonary Complications After Hematopoietic Stem Cell Transplantation Am. J. Roentgenol., February 1, 2005; 184(2): 629 - 637. [Full Text] [PDF] D. H. Kaplan, B. E. Anderson, J. M. McNiff, D. Jain, M. J. Shlomchik, and W. D. Shlomchik Target Antigens Determine Graft-versus-Host Disease Phenotype J. Immunol., November 1, 2004; 173(9): 5467 - 5475. [Abstract] [Full Text] [PDF]

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