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Prepublished online as a Blood First Edition Paper on October 31, 2002; DOI 10.1182/blood-2002-06-1837.
Submitted June 21, 2002
Accepted October 29, 2002
CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays
Carl-Magnus Hogerkorp, Sven Bilke, Thomas Breslin, Sigurdur Ingvarsson, and Carl A K Borrebaeck*
Department of Immunotechnology, Lund University, Lund, Sweden
Department of Complex Systems, Lund University, Lund, Sweden
* Corresponding author; email: Carl.Borrebaeck{at}immun.lth.se.
A number of studies have implicated a role for the cell surface glycoprotein CD44 in several biological events, such as lymphopoiesis, homing, lymphocyte activation and apoptosis. We have earlier reported that signaling via CD44 on naive B cells in addition to BCR and CD40 engagement generated a germinal center like phenotype. To further characterize the global role of CD44 in B differentiation, we examined the expression profile of human B cells cultured in vitro in the presence or absence of CD44 ligation, together with anti-Ig and anti-CD40 antibodies. The data sets derived from DNA microarrays were analyzed employing a novel statistical analysis scheme created to retrieve the most likely expression pattern of CD44 ligation. Our results show that genes, such as IL-6, IL-1 and  2-AR were specifically up-regulated by CD44 ligation, suggesting a novel role for CD44 in immunoregulation and inflammation.
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