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Prepublished online as a Blood First Edition Paper on September 19, 2002; DOI 10.1182/blood-2002-06-1881.
Submitted July 5, 2002
Accepted September 10, 2002
LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3
Takeshi Senga, Shotaro Iwamoto, Tsunehiko Yoshida, Takashi Yokota, Koichi Adachi, Eiichi Azuma, Michinari Hamaguchi, and Takashi Iwamoto*
Department of Molecular Pathogenesis, Nagoya University School of Medicine, Nagoya, Japan
Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
Radioisotope Research Center Medical Division, Nagoya University School of Medicine, Nagoya, Japan
Department of Pediatrics and Clinical Immunology, Mie University School of Medicine, Tsu, Japan
Division of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
Radioisotope Research Center Medical Division, Nagoya University School of Medicine, Nagoya, Japan; Radioisotope Research Center Medical Division, Nagoya University School of Medicine, Nagoya, Japan
* Corresponding author; email: iwamoto{at}med.nagoya-u.ac.jp.
G protein-coupled receptors (GPCRs) transduce the signal of a wide variety of chemokines, cytokines, neurotransmitters, hormones, odorants and others to regulate the biological homeostasis including hematopoiesis and immunity. Here we report the molecular cloning of LSSIG, which is a novel murine orphan GPCR with the highest homology to human GPR43. The mRNA expression of LSSIG was clearly induced in M1 leukemia cells during the leukemia inhibitory factor (LIF)-induced differentiation to macrophages and the induction was evidently STAT3-dependent. GPR43 expression was also strongly induced in HL-60 and U937 leukemia cells during the differentiation to monocytes. Further analysis showed that the expression of both LSSIG and GPR43 is highly restricted in hematopoietic tissues. Cytokine-stimulation induced LSSIG and GPR43 in bone marrow cells, and monocytes and neutrophils, respectively. These results suggest that LSSIG and GPR43 would play pivotal roles in differentiation and immune response of monocytes and granulocytes.
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