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Prepublished online as a Blood First Edition Paper on September 19, 2002; DOI 10.1182/blood-2002-07-1957. This Article Full Text (PDF) All Versions of this Article: 2002-07-1957v1 101/3/1024    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mueller, Y. M Articles by Katsikis, P. D Search for Related Content PubMed PubMed Citation Articles by Mueller, Y. M Articles by Katsikis, P. D Social Bookmarking                   What's this? Submitted July 2, 2002 Accepted September 4, 2002 IL-15 enhances survival and function of HIV-specific CD8+ T cells Yvonne M Mueller, Paul M Bojczuk, E Scott Halstead, Alfred H J Kim, James Witek, John D Altman, and Peter D Katsikis* Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA * Corresponding author; email: katsikis{at}drexel.edu. HIV-specific CD8+ T cells are prone to undergo apoptosis and this may affect their ability to control HIV infection. Since CD8-mediated immune responses play a key role in controlling HIV infection, enhancing the survival and effector function of HIV-specific CD8+ T cells may augment their ability to control HIV virus. We show here that IL-15 potently inhibits spontaneous and CD95/Fas-induced apoptosis of HIV-specific CD8+ T cells. IL-15 inhibits apoptosis in both CD45RA-CD62L- and CD45RA+CD62L- effector memory subpopulations of these cells. Furthermore, IL-15 greatly enhances the survival of HIV-specific CD8+ T cells in long-term cultures. Finally, IL-15 directly enhances activation, IFN production and direct ex vivo cytotoxicity of HIV-specific CD8+ T cells. Thus, IL-15 potently enhances the survival and effector function of HIV-specific CD8+ T cells and therefore may prove useful in augmenting the antiviral function of these cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. D. Eberly, M. Kader, W. Hassan, K. A. Rogers, J. Zhou, Y. M. Mueller, M. J. Mattapallil, M. Piatak Jr., J. D. Lifson, P. D. Katsikis, et al. Increased IL-15 Production Is Associated with Higher Susceptibility of Memory CD4 T Cells to Simian Immunodeficiency Virus during Acute Infection J. Immunol., February 1, 2009; 182(3): 1439 - 1448. [Abstract] [Full Text] [PDF] A. I. Kokaji, D. L. Hockley, and K. P. Kane IL-15 Transpresentation Augments CD8+ T Cell Activation and Is Required for Optimal Recall Responses by Central Memory CD8+ T Cells J. Immunol., April 1, 2008; 180(7): 4391 - 4401. [Abstract] [Full Text] [PDF] Y. M. Mueller, D. H. Do, S. R. Altork, C. M. Artlett, E. J. Gracely, C. D. Katsetos, A. Legido, F. Villinger, J. D. Altman, C. R. Brown, et al. IL-15 Treatment during Acute Simian Immunodeficiency Virus (SIV) Infection Increases Viral Set Point and Accelerates Disease Progression despite the Induction of Stronger SIV-Specific CD8+ T Cell Responses J. Immunol., January 1, 2008; 180(1): 350 - 360. [Abstract] [Full Text] [PDF] Y. M. Mueller, C. Petrovas, D. H. Do, S. R. Altork, T. Fischer-Smith, J. Rappaport, J. D. Altman, M. G. Lewis, and P. D. Katsikis Early Establishment and Antigen Dependence of Simian Immunodeficiency Virus-Specific CD8+ T-Cell Defects J. Virol., October 15, 2007; 81(20): 10861 - 10868. [Abstract] [Full Text] [PDF] M. C. G. Marcondes, T. H. Burdo, S. Sopper, S. Huitron-Resendiz, C. Lanigan, D. Watry, C. Flynn, M. Zandonatti, and H. S. Fox Enrichment and Persistence of Virus-Specific CTL in the Brain of Simian Immunodeficiency Virus-Infected Monkeys Is Associated with a Unique Cytokine Environment J. Immunol., May 1, 2007; 178(9): 5812 - 5819. [Abstract] [Full Text] [PDF] A. Hryniewicz, D. A. Price, M. Moniuszko, A. Boasso, Y. Edghill-Spano, S. M. West, D. Venzon, M. Vaccari, W.-P. Tsai, E. Tryniszewska, et al. Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques J. Immunol., March 15, 2007; 178(6): 3492 - 3504. [Abstract] [Full Text] [PDF] P. Zimbwa, A. Milicic, J. Frater, T. J. Scriba, A. Willis, P. J. R. Goulder, T. Pillay, H. Gunthard, J. N. Weber, H.-T. Zhang, et al. Precise Identification of a Human Immunodeficiency Virus Type 1 Antigen Processing Mutant J. 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Mosmann HIV-Specific Cytotoxic Cell Frequencies Measured Directly Ex Vivo by the Lysispot Assay Can Be Higher or Lower Than the Frequencies of IFN-{gamma}-Secreting Cells: Anti-HIV Cytotoxicity Is Not Generally Impaired Relative to Other Chronic Virus Responses J. Immunol., February 15, 2006; 176(4): 2662 - 2668. [Abstract] [Full Text] [PDF] Y. M. Mueller, C. Petrovas, P. M. Bojczuk, I. D. Dimitriou, B. Beer, P. Silvera, F. Villinger, J. S. Cairns, E. J. Gracely, M. G. Lewis, et al. Interleukin-15 Increases Effector Memory CD8+ T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques J. Virol., April 15, 2005; 79(8): 4877 - 4885. [Abstract] [Full Text] [PDF] R. M. Johnson Murine Oviduct Epithelial Cell Cytokine Responses to Chlamydia muridarum Infection Include Interleukin-12-p70 Secretion Infect. Immun., July 1, 2004; 72(7): 3951 - 3960. [Abstract] [Full Text] [PDF] J. J. Lum, D. J. Schnepple, Z. Nie, J. Sanchez-Dardon, G. L. Mbisa, J. Mihowich, N. Hawley, S. Narayan, J. E. Kim, D. H. Lynch, et al. Differential Effects of Interleukin-7 and Interleukin-15 on NK Cell Anti-Human Immunodeficiency Virus Activity J. Virol., June 1, 2004; 78(11): 6033 - 6042. [Abstract] [Full Text] [PDF] L. E. Gamadia, E. M. M. van Leeuwen, E. B. M. Remmerswaal, S.-L. Yong, S. Surachno, P. M. E. Wertheim-van Dillen, I. J. M. ten Berge, and R. A. W. van Lier The Size and Phenotype of Virus-Specific T Cell Populations Is Determined by Repetitive Antigenic Stimulation and Environmental Cytokines J. Immunol., May 15, 2004; 172(10): 6107 - 6114. [Abstract] [Full Text] [PDF] C. Petrovas, Y. M. Mueller, I. D. Dimitriou, P. M. Bojczuk, K. C. Mounzer, J. Witek, J. D. Altman, and P. D. Katsikis HIV-Specific CD8+ T Cells Exhibit Markedly Reduced Levels of Bcl-2 and Bcl-xL J. Immunol., April 1, 2004; 172(7): 4444 - 4453. [Abstract] [Full Text] [PDF]

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