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 Prepublished online as a Blood First Edition Paper on October 3, 2002; DOI 10.1182/blood-2002-07-2011.

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Submitted July 17, 2002
Accepted September 20, 2002

Successful treatment of juvenile myelomonocytic leukemia relapsing post stem cell transplant using donor lymphocyte infusion

Austen Worth, Kanchan Rao*, David Webb, Judith Chessells, Jane Passmore, and Paul Veys

Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, United Kingdom

* Corresponding author; email: raok{at}gosh.nhs.uk.

Juvenile Myelomonocytic Leukaemia (JMML) is a rare paediatric malignancy. Haematopoietic stem cell transplant (SCT) is the only curative approach. However, relapse post SCT remains the major cause of treatment failure. Unlike most other paediatric malignancies, JMML maybe susceptible to a graft versus leukaemia (GVL) effect although unlike Chronic Myeloid leukaemia, reports of response to donor lymphocyte infusions (DLI) remain scanty. This is the first report that describes the successful treatment of relapsed JMML with DLI in the absence of further chemotherapy and provides definite proof of a GVL effect in JMML.


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