|
|
Prepublished online as a Blood First Edition Paper on October 17, 2002; DOI 10.1182/blood-2002-07-2213.
Submitted July 23, 2002
Accepted September 30, 2002
Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells
Eiichi Morii, Keisuke Oboki, Tomoko Jippo, and Yukihiko Kitamura*
Department of Pathology, Medical School/Graduate School of Frontier Bioscience, Osaka University, Osaka, Japan
* Corresponding author; email: kitamura{at}patho.med.osaka-u.ac.jp.
MITF is a basic-helix-loop-helix leucine zipper transcription factor and is encoded by mi locus. The mi/mi mutant mice showed a significant decrease of skin mast cells in C57BL/6 (B6) genetic background but not in WB genetic background. Kit Ligand (KitL) is the most important growth factor for development of mast cells, and the decrease of skin mast cells in B6-mi/mi mice was attributable to the reduced expression of c-kit receptor tyrosine kinase (KIT) that is a receptor for KitL. However, the expression level of KIT in WB-mi/mi mast cells was comparable with that of B6-mi/mi mast cells, suggesting that a factor compensating the reduced expression of KIT was present in WB-mi/mi mice. By linkage analysis, such a factor was mapped on chromosome 10. The mapped position was closely located to the KitL locus. Two alternative spliced forms are known in KitL mRNA; KL-1 and KL-2. Soluble KitL, which is important for development of skin mast cells, is produced more efficiently from KL-1 mRNA than from KL-2 mRNA. The KL-1 / KL-2 ratio was higher in WB-mi/mi than in B6-mi/mi mice, suggesting that the larger amount of soluble KitL may compensate for the reduced expression of KIT in WB-mi/mi mice.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
T. Oda, T. Tian, M. Inoue, J.-i. Ikeda, Y. Qiu, M. Okumura, K. Aozasa, and E. Morii
Tumorigenic Role of Orphan Nuclear Receptor NR0B1 in Lung Adenocarcinoma
Am. J. Pathol.,
September 1, 2009;
175(3):
1235 - 1245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Sawada, S. Shimizu, T. Tamatani, S. Kanegasaki, H. Saito, A. Tanaka, N. Kambe, T. Nakahata, and H. Matsuda
Stem Cell Factor Has a Suppressive Activity to IgE-Mediated Chemotaxis of Mast Cells
J. Immunol.,
March 15, 2005;
174(6):
3626 - 3632.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Oboki, E. Morii, and Y. Kitamura
Deficient Eosinophil Chemotaxis-Promoting Activity of Genetically Normal Mast Cells Transplanted into Subcutaneous Tissue of Mitfmi-vga9/Mitfmi-vga9 Mice: Comparison of the Activity and Mast Cell Distribution Pattern with KitW/KitW-vMice
Am. J. Pathol.,
October 1, 2004;
165(4):
1141 - 1150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Morii, K. Oboki, K. Ishihara, T. Jippo, T. Hirano, and Y. Kitamura
Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments
Blood,
September 15, 2004;
104(6):
1656 - 1661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Morii, A. Ito, T. Jippo, Y.-i. Koma, K. Oboki, T. Wakayama, S. Iseki, M. L. Lamoreux, and Y. Kitamura
Number of Mast Cells in the Peritoneal Cavity of Mice: Influence of Microphthalmia Transcription Factor through Transcription of Newly Found Mast Cell Adhesion Molecule, Spermatogenic Immunoglobulin Superfamily
Am. J. Pathol.,
August 1, 2004;
165(2):
491 - 499.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
