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Prepublished online as a Blood First Edition Paper on January 23, 2003; DOI 10.1182/blood-2002-07-2290. This Article Full Text (PDF) All Versions of this Article: 2002-07-2290v1 101/10/4219    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kimura, S. Articles by Maekawa, T. Search for Related Content PubMed PubMed Citation Articles by Kimura, S. Articles by Maekawa, T. Social Bookmarking                   What's this? Submitted July 29, 2002 Accepted January 9, 2003 Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma Shinya Kimura*, Akiyo Horie, Yoshiyuki Hiki, Chie Yamamoto, Satoru Suzuki, Junya Kuroda, Masayo Deguchi, Gen-ichi Kato, Takahiro Karasuno, Akira Hiraoka, Toshikazu Yoshikawa, and Taira Maekawa Department of Transfusion Medicine, Kyoto University Hospital, Kyoto, Japan Department of Medicine, Daiko Medical Center, Nagoya, Japan Department of Clinical and Laboratory Medicine, Fukui Medical University, Fukui, Japan Department of Internal Medicine and Pathology, Kyoto Second Red Cross Hospital, Kyoto, Japan Fifth Department of Internal Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan * Corresponding author; email: shkimu{at}kuhp.kyoto-u.ac.jp. We describe herein a case of nephrotic syndrome (NS) following allogeneic bone marrow transplantation (allo-BMT) for natural killer cell leukemia/lymphoma. Histological studies defined the diagnosis as crescentic glomerulonephritis with massive IgA deposition, which have never been reported in NS cases following allo-BMT. A majority of the massive infiltrated cells in the interstice were CD3(+)CD4(-)CD8(+) T cells derived from the donor. Mesangial deposition of Haemophilus parainfluenza outer membrane (OMHP) antigen and decreased glycosylation of the IgA1 hinge in the recipient's samples, with which we recently reported on the pathogenesis of IgA nephropathy and its association, were observed. Further, IgA antibody against OMHP titer of the donor serum was as high as other IgA nephropathy cases. These findings suggested that NS, crescentic glomerulonephritis, of this case was caused as one of the forms of chronic GVHD and IgA deposition was associated with Haemophilus parainfluenza and decreased glycosylation of the IgA1 hinge. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Brukamp, A. M. Doyle, R. D. Bloom, N. Bunin, J. E. Tomaszewski, and B. Cizman Nephrotic Syndrome after Hematopoietic Cell Transplantation: Do Glomerular Lesions Represent Renal Graft-versus-Host Disease? Clin. J. Am. Soc. Nephrol., July 1, 2006; 1(4): 685 - 694. [Abstract] [Full Text] [PDF] J. Kuroda, S. Kimura, H. Segawa, Y. Kobayashi, T. Yoshikawa, Y. Urasaki, T. Ueda, F. Enjo, H. Tokuda, O. G. Ottmann, et al. The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate Blood, September 15, 2003; 102(6): 2229 - 2235. [Abstract] [Full Text] [PDF]

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