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Prepublished online as a Blood First Edition Paper on December 27, 2002; DOI 10.1182/blood-2002-08-2383. This Article Full Text (PDF) All Versions of this Article: 2002-08-2383v1 101/9/3568    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lentzsch, S. Articles by Mapara, M. Y Search for Related Content PubMed PubMed Citation Articles by Lentzsch, S. Articles by Mapara, M. Y Social Bookmarking                   What's this? Submitted August 8, 2002 Accepted December 19, 2002 Macrophage inflammatory protein-1alpha (MIP-1) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells Suzanne Lentzsch*, Margarete Gries, Martin Janz, Ralf Bargou, Bernd Dorken, and Markus Y Mapara Department of Hematology and Oncology, University Medical Center Charite Campus Buch and Campus Virchow Klinikum, Humboldt University, Berlin, Germany * Corresponding author; email: lentzsch{at}rrk-berlin.de. Recently it has been demonstrated that MIP-1 is crucially involved in the development of osteolytic bone lesions in MM. The current study was designed to determine the direct effects of MIP-1 on MM cells. Thus, we were able to demonstrate that MIP-1acts as a potent growth, survival and chemotactic factor in MM cells. MIP-1-induced signaling involved activation of the AKT/PKB and the MAPK pathway. In addition, inhibition of AKT activation by the PI3-Kinase (PI3-K) inhibitors did not influence MAPK activation, suggesting that there is no crosstalk between MIP-1-dependent activation of the PI3-K/AKT and ERK pathway. Our data suggest that besides the role of development of osteolytic bone destruction, MIP-1 also directly affects cell signaling pathways mediating growth, survival and migration in MM cells and provide evidence that MIP-1 might play a pivotal role in the pathogenesis of MM. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Pal, M. Janz, D. L. Galson, M. Gries, S. Li, K. Johrens, I. Anagnostopoulos, B. Dorken, M. Y. Mapara, L. Borghesi, et al. C/EBP{beta} regulates transcription factors critical for proliferation and survival of multiple myeloma cells Blood, October 29, 2009; 114(18): 3890 - 3898. [Abstract] [Full Text] [PDF] O. 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