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Prepublished online as a Blood First Edition Paper on December 12, 2002; DOI 10.1182/blood-2002-08-2432. This Article Full Text (PDF) All Versions of this Article: 2002-08-2432v1 101/8/3082    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Potter, K. N Articles by Stevenson, F. K Search for Related Content PubMed PubMed Citation Articles by Potter, K. N Articles by Stevenson, F. K Social Bookmarking                   What's this? Submitted August 9, 2002 Accepted December 3, 2002 Features of the over-expressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire Kathleen N Potter*, Jenny A Orchard, Eustacia Critchley, C I Mockridge, Annette Jose, and Freda K Stevenson Immunology, Tenovus Laboratory, Southampton, Hampshire, United Kingdom Haematology and Oncology, Royal Bournemoth Hospital, Bournemouth, Hampshire, United Kingdom * Corresponding author; email: kp1{at}soton.ac.uk. CLL comprises two subsets, distinguished by expression of unmutated or mutated VH genes, with the former having a worse prognosis. Biased usage of the V1-69 gene is found in unmutated cases, and is combined with selected D gene segments and JH6. The question of whether this is a CLL-associated feature, or if it mirrors the normal B pattern, is controversial. Since CLL is a disease of the elderly, where changes in the B-cell repertoire may occur, we have analyzed V1-69 usage in the elderly (>75yr) population. Using MoAb G6, specific for 51p1-related V1-69 alleles, we found no increased expression with age. In 51p1-encoded IgM, CDR3 length, and frequency of D and JH genes, were similar to the healthy young, and distinct from CLL. These findings support the concept that CLL arises from B cells driven by antigen/superantigen, and is not a stochastic event in the elderly B cell population. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. F. Widhopf II, C. J. Goldberg, T. L. Toy, L. Z. Rassenti, W. G. Wierda, J. C. Byrd, M. J. Keating, J. G. Gribben, K. R. Rai, and T. J. 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