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 Prepublished online as a Blood First Edition Paper on October 3, 2002; DOI 10.1182/blood-2002-08-2436.

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2002-08-2436v1
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Submitted August 9, 2002
Accepted September 18, 2002

Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants

Herve Avet-Loiseau*, Richard Garand, Laurence Lode, Jean-Luc Harousseau, and Regis Bataille

Laboratory of Hematology, University Hospital, Nantes, France
Clinical Hematology Department, University Hospital, Nantes, France

* Corresponding author; email: havetloiseau{at}chu-nantes.fr.

In an attempt to address the issue of cytogenetic features of multiple myeloma (MM) variants, we have analyzed a series of 8 IgM, 9 IgD, 2 IgE, and 14 nonsecretory (NS) MM cases using fluorescence in situ hybridization. A very high incidence (83%) of t(11;14)(q13;q32) was detected in the IgM (7/8), IgE (2/2) and NS (11/14) MM cases, but not in the IgD cases (2/9). Of note, no t(4;14) was observed in this cohort of patients. This increased incidence of t(11;14) was associated with 2 dominant features in these variants: a "lymphoplasmacytic" presentation mainly in IgM MM, and a lower secreting capacity in the others, two features previously associated with t(11;14). Of major interest, t(11;14) was never observed in Waldenstrom macroglobulinemia, or in IgG/IgA "lymphomasmacytic" lymphomas. Thus, for unknown reasons, t(11;14) is the hallmark of IgM, IgE, and NS MM, (but not IgD MM), with a 5-fold increase of its incidence compared to that of IgG and IgA MM.


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