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Prepublished online as a Blood First Edition Paper on January 30, 2003; DOI 10.1182/blood-2002-08-2550.

Submitted August 21, 2002
Accepted January 4, 2003
A unique atrial primary cardiac lymphoma mimicking myxoma presenting with embolic stroke: a case report
Michael M Quigley*, Eric Schwartzman, Pamela D Boswell, Rebecca L Christensen, Lisa A Gleason, Robert W Sharpe, and Thomas A d'Amato
Department of Pathology, Naval Medical Center San Diego, San Diego, CA, USA
Department of Cardiology, Naval Medical Center San Diego, San Diego, CA, USA
Department of Cardiothoracic Surgery, Naval Medical Center San Diego, San Diego, CA, USA
Department of Pathology, Scripps Clinic, La Jolla, CA, USA
* Corresponding author; email: mmquigley{at}nmcsd.med.navy.mil.
An immunocompetent 29 year-old male presented with an embolic stroke from an unusual primary cardiac lymphoma. The cardiac lesion consisted of a polypoid, left atrial, mural fibrin thrombus with anaplastic tumor cells lining the surface of the clot. Histologic, immunophenotypic, and molecular characterization were consistent with a diagnosis of CD30-positive large B-cell lymphoma with anaplastic cytology. While tumor emboli from invasive primary cardiac lymphomas have been reported, this non-invasive fibrin thrombus-associated lymphoma appears to be unique and previously unreported.

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