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Prepublished online as a Blood First Edition Paper on December 19, 2002; DOI 10.1182/blood-2002-08-2638. This Article Full Text (PDF) All Versions of this Article: 2002-08-2638v1 101/8/3106    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Masci, A. M Articles by Racioppi, L. Search for Related Content PubMed PubMed Citation Articles by Masci, A. M Articles by Racioppi, L. Social Bookmarking                   What's this? Submitted August 29, 2002 Accepted November 27, 2002 Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B-lymphopenia Anna M Masci, Giovannella Palmieri, Laura Vitiello, Liliana Montella, Francesco Perna, Paola Orlandi, Gianfranco Abbate, Serafino Zappacosta, Raffaele De Palma, and Luigi Racioppi* Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Naples, Italy Department of Molecular and Clinical Oncology, Federico II University of Naples, Naples, Italy Laboratory of Clinical Chemistry and Microbiology, Monaldi Hospital, Naples, Italy Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy Divisione di Immunologia e Malattie Infettive, Ospedale Bambin Gesu, Tor Vergata, University of Rome, Rome, Italy * Corresponding author; email: racioppi{at}unina.it. A subgroup of thymoma patients is affected by severe immunodeficiency clinically resembling an HIV infection (Good's Syndrome). These individuals are characterized by B-lymphopenia with B-lymphopoiesis deficiency. To investigate the pathogenesis of this unique condition, we studied T-cell repertoire in blood and bone marrow samples by hetherogeneity length analysis of CDR3 beta variable regions of the T-cell receptor (Spectratyping). While no alterations were found in the peripheral blood, we detected an oligoclonal population of BV8 CD8+ T-cells in five out of five bone marrow samples. No lymphocyte expansions were found in the bone marrow of two thymoma patients with normal B-cell counts, two healthy donors and three patients with thymoma-unrelated diseases. These data suggest that an immune response toward an unknown antigen is taking place in the marrow of B-lymphopenic thymoma patients. We propose that BV8 CD8+ T cells may play a role in the pathogenesis of this immunodeficiency syndrome. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. de Laurentiis, L. Vitiello, L. Racioppi, F. Perna, M. Galgani, G. Merola, P. Carratu, M. Maniscalco, S. Marsico, and M. Sofia CD8+ T-cell alveolitis in familial pulmonary alveolar microlithiasis Eur. Respir. J., July 1, 2007; 30(1): 165 - 171. [Abstract] [Full Text] [PDF] P. Striano, F. Tortora, A. Evoli, G. Palmieri, A. Elefante, F. Zara, P. E. Tarr, and S. Striano Periodic Myoclonus Due to Cytomegalovirus Encephalitis in a Patient With Good Syndrome Arch Neurol, February 1, 2007; 64(2): 277 - 279. [Abstract] [Full Text] [PDF] R. De Palma, F. Del Galdo, G. Abbate, M. Chiariello, R. Calabro, L. Forte, G. Cimmino, M. F. Papa, M. G. Russo, G. Ambrosio, et al. Patients With Acute Coronary Syndrome Show Oligoclonal T-Cell Recruitment Within Unstable Plaque: Evidence for a Local, Intracoronary Immunologic Mechanism Circulation, February 7, 2006; 113(5): 640 - 646. [Abstract] [Full Text] [PDF]

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