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Prepublished online as a Blood First Edition Paper on January 16, 2003; DOI 10.1182/blood-2002-09-2778.

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Submitted September 11, 2002
Accepted January 11, 2003

Utility of FDG-PET scanning in lymphoma by WHO classification

Rebecca Elstrom*, Liang Guan, Khozaim Nakhoda, Gary Baker, Jo-Anne Vergilio, Hongming Zhuang, Stephanie Pitsilos, Adam Bagg, Lisa Downs, Amit Mehrotra, Scott Kim, Abass Alavi, and Stephen J Schuster

Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Department of Nuclear Medicine, University of Pennsylvania, Philadelphia, PA, USA
Department of Laboratory Medicine and Pathology, University of Pennsylvania, Philadelphia, PA, USA

* Corresponding author; email: relstrom{at}mail.med.upenn.edu.

We retrospectively evaluated FDG-PET scans in 172 patients with lymphoma and correlated results with pathologic diagnosis using the WHO classification system. In total, FDG-PET detected disease in at least one site in 161 patients (94%) and failed to detect disease in 11 patients (6%). The most frequent lymphoma diagnoses were diffuse large B-cell lymphoma (LBCL; n=51), Hodgkin lymphoma (HL; n=47), follicular lymphoma (FL; n=42), marginal zone lymphoma (MZL; n=12), mantle cell lymphoma (MCL; n=7) and peripheral T-cell lymphoma (PTCL; n=5). FDG-PET detected disease in 100% of patients with LBCL and MCL, and 98% of patients with HL and FL. In contrast, FDG-PET detected disease in only 67% of MZL and 40% of PTCL. Comparison with bone marrow biopsies showed that FDG-PET was not reliable for detection of bone marrow involvement in any lymphoma subtype.


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