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Prepublished online as a Blood First Edition Paper on November 14, 2002; DOI 10.1182/blood-2002-09-2801. This Article Full Text (PDF) All Versions of this Article: 2002-09-2801v1 101/6/2374    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Santra, M. Articles by Shaughnessy, J. Search for Related Content PubMed PubMed Citation Articles by Santra, M. Articles by Shaughnessy, J. Social Bookmarking                   What's this? Submitted September 13, 2002 Accepted October 16, 2002 A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lack FGFR3 expression but maintain an IGH/MMSET fusion transcript Madhumita Santra, Fenghuang Zhan, Erming Tian, Bart Barlogie, and John Shaughnessy* Myeloma Institute for Research and Therapy, University of Arkansas for the Medical Sciences, Little Rock, AR, USA * Corresponding author; email: shaughnessyjohn{at}uams.edu. Previous studies have revealed that that approximately 10-15% of multiple myeloma (MM) are characterized by a reciprocal t(4;14)(p16;q32) translocation that activates expression of FGFR3 and creates an IGH/MMSET fusion transcript. Current data suggests that activation of FGFR3 is the oncogenic consequence of this rearrangement. Using a combination of microarray profiling, RT-PCR and interphase FISH we show that 32 of 178 newly diagnosed MM harbor the t(4;14)(p16;q32). Importantly, 32% of these cases lack expression of FGFR3, yet express MMSET and have an IGH/MMSET fusion transcript. Interphase FISH showed that whereas the IGH/MMSET fusion was present in greater than 80% of the clonotypic plasma cells in these novel cases, there was typically a complete loss of one copy of FGFR3. These data indicate that the t(4;14)(p16;q32) and loss of FGFR3 occurred very early and suggests that activation of MMSET, not FGFR3, may be the critical transformation event of this recurrent translocation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Anguiano, S. A. Tuchman, C. Acharya, K. Salter, C. Gasparetto, F. Zhan, M. Dhodapkar, J. Nevins, B. Barlogie, J. D. Shaughnessy Jr, et al. Gene Expression Profiles of Tumor Biology Provide a Novel Approach to Prognosis and May Guide the Selection of Therapeutic Targets in Multiple Myeloma J. Clin. 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