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Prepublished online as a Blood First Edition Paper on January 2, 2003; DOI 10.1182/blood-2002-09-2817. This Article Full Text (PDF) All Versions of this Article: 2002-09-2817v1 101/9/3594    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ikeda, K. Articles by Iwamoto, I. Search for Related Content PubMed PubMed Citation Articles by Ikeda, K. Articles by Iwamoto, I. Social Bookmarking                   What's this? Submitted September 16, 2002 Accepted December 24, 2002 Mast cells produce interleukin-25 upon FcRI-mediated activation Kei Ikeda, Hiroshi Nakajima*, Kotaro Suzuki, Shin-ichiro Kagami, Koichi Hirose, Akira Suto, Yasushi Saito, and Itsuo Iwamoto Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan * Corresponding author; email: nakajimh{at}intmed02.m.chiba-u.ac.jp. Interleukin (IL)-25 is a recently described T helper 2 (Th2) cell-derived cytokine that belongs to IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non-T cell population. Here, we show that mast cells are also potent IL-25-producing cells. When bone marrow-derived mast cells (BMMCs) were stimulated by IgE cross-linking, IL-25 mRNA was induced within 30 min in a calcineurin-dependent manner and the levels of IL-25 mRNA were comparable to that of activated Th2 cells. Production of IL-25 by mast cells was also detected at protein levels by immunoblotting. 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