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Prepublished online as a Blood First Edition Paper on April 10, 2003; DOI 10.1182/blood-2002-09-2866. This Article Full Text (PDF) All Versions of this Article: 2002-09-2866v1 102/3/1131    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ottinger, H. D Articles by Grosse-Wilde, H. Search for Related Content PubMed PubMed Citation Articles by Ottinger, H. D Articles by Grosse-Wilde, H. Social Bookmarking                   What's this? Submitted September 19, 2002 Accepted March 21, 2003 Hematopoietic stem cell transplantation: contrasting the outcome of transplantations from HLA-identical siblings, partially HLA-mismatched related and HLA-matched unrelated donors Hellmut D Ottinger, Stanislav Ferencik, Dietrich W Beelen, Monika Lindemann, Rudolf Peceny, Ahmet H Elmaagacli, Johannes Huesing, and Hans Grosse-Wilde* Institute for Immunology, University Hospital of Essen, Essen, Germany Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany * Corresponding author; email: immunologie{at}uni-essen.de. Allogeneic hematopoietic stem cell transplantation (HSCT) is a proven curative therapy for many hematological malignancies. HSCT from HLA-identical sibling donors (ISD) is still the golden standard. For the remaining 70% of the patients lacking an ISD alternative (partially) HLA-matched family donors (MFD) and HLA-matched unrelated donors (MUD) are now widely accepted. However, it is presently unclear whether outcome after HSCT from MFD or MUD is superior. Thus, the classical clinical endpoints after HSCT from ISD (n=138), MFD (n=86), and MUD (n=101) were compared by means of uni- and multivariate statistical analyses. MFD transplants with HLA class II (DRB1±DQB1) mismatches in graft-versus-host (GvH) direction showed an increased risk of grades II-IV graft-versus-host disease, and MFD transplants with more than a single HLA class I (A±B±C) mismatch in host-versus-graft (HvG) direction were associated with a higher risk of graft failure. However, no significant difference in overall survival was detectable between the three study groups after adjustment for the main predictors of transplant outcome. Thus, for patients lacking an ISD, an already identified MFD with an HLA-DRB1±DQB1 mismatch in GvH- or a combined HLA-A±B±C mismatch in HvG-direction should only be accepted in clinical urgent settings leaving no time to identify a MUD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Xiao-Jun, X. Lan-Ping, L. Kai-Yan, L. Dai-Hong, W. Yu, C. Huan, C. Yu-Hong, H. Wei, W. Jing-Zhi, C. Yao, et al. Partially Matched Related Donor Transplantation Can Achieve Outcomes Comparable with Unrelated Donor Transplantation for Patients with Hematologic Malignancies Clin. Cancer Res., July 15, 2009; 15(14): 4777 - 4783. [Abstract] [Full Text] [PDF] J. Schetelig, M. Bornhauser, C. Schmid, B. Hertenstein, R. Schwerdtfeger, H. Martin, M. Stelljes, U. Hegenbart, K. Schafer-Eckart, M. Fussel, et al. Matched Unrelated or Matched Sibling Donors Result in Comparable Survival After Allogeneic Stem-Cell Transplantation in Elderly Patients With Acute Myeloid Leukemia: A Report From the Cooperative German Transplant Study Group J. Clin. Oncol., November 10, 2008; 26(32): 5183 - 5191. [Abstract] [Full Text] [PDF] M. Ditschkowski, A. H. Elmaagacli, R. Trenschel, R. Peceny, M. Koldehoff, C. Schulte, and D. W. Beelen T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donors Haematologica, April 1, 2007; 92(4): 558 - 561. [Abstract] [Full Text] [PDF] J. C. Fischer, H. Ottinger, S. Ferencik, M. Sribar, M. Punzel, D. W. Beelen, M. A. Schwan, H. Grosse-Wilde, P. Wernet, and M. Uhrberg Relevance of C1 and C2 Epitopes for Hemopoietic Stem Cell Transplantation: Role for Sequential Acquisition of HLA-C-Specific Inhibitory Killer Ig-Like Receptor J. 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Oncol., December 20, 2006; 24(36): 5695 - 5702. [Abstract] [Full Text] [PDF] D. W. Beelen, H. D. Ottinger, S. Ferencik, A. H. Elmaagacli, R. Peceny, R. Trenschel, and H. Grosse-Wilde Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias Blood, March 15, 2005; 105(6): 2594 - 2600. [Abstract] [Full Text] [PDF]

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