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Prepublished online as a Blood First Edition Paper on December 12, 2002; DOI 10.1182/blood-2002-09-2876. This Article Full Text (PDF) All Versions of this Article: 2002-09-2876v1 101/8/3052    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fehniger, T. A Articles by Caligiuri, M. A Search for Related Content PubMed PubMed Citation Articles by Fehniger, T. A Articles by Caligiuri, M. A Social Bookmarking                   What's this? Submitted September 20, 2002 Accepted October 16, 2002 CD56bright Natural Killer Cells are Present in Human Lymph Nodes and are Activated by T cell Derived IL-2: a Potential New Link between Adaptive and Innate Immunity Todd A Fehniger, Megan A Cooper, Gerard J Nuovo, Marina Cella, Fabio Facchetti, Marco Colonna, and Michael A Caligiuri* Department of Internal Medicine, Washington University, St. Louis, MO, USA; Internal Medicine, Division of Hematology/Oncology, Ohio State University, Columubus, OH, USA Internal Medicine, Division of Hematology/Oncology, Ohio State University, Columubus, OH, USA; Department of Veterinary Biosciences, Ohio State University, Columbus, OH, USA Department of Pathology, Ohio State University, Columbus, OH, USA Department of Pathology and Immunology, Washington University, St. Louis, MO, USA Instituto di Anatomia Patologica, Spedali Civili di Bescia, Universita di Brescia, Bescia, Italy * Corresponding author; email: caligiuri-1{at}medctr.osu.edu. Natural killer (NK) cells are innate lymphocytes that provide cytokines critical for early host defense against pathogens. One subset of human NK cells (CD56bright) constitutively expresses the high affinity IL-2 receptor and produces immunoregulatory cytokines. Here, we demonstrate that CD56bright NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high affinity IL-2 receptor, costimulates CD56bright NK cells to secrete IFN-. Thus, adaptive immunoregulators influence innate cytokine production, which in turn may influence the developing antigen-specific immune response. These data show a dynamic interaction between innate and adaptive human lymphocytes, and emphasize the importance of studying interactions between immune components to understand the immune response as a whole. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Gruenbacher, H. 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